Effects of an impermeable layer on pore pressure response to tsunami-like inundation.

Tsunami hazards have been observed to cause soil instability resulting in substantial damage to coastal infrastructure. Studying this problem is difficult owing to tsunamis' transient, non-uniform and large loading characteristics. To create realistic tsunami conditions in a laboratory environment, we control the body force using a centrifuge facility.

Simulating Tsunami Inundation and Soil Response in a Large Centrifuge.

Tsunamis are rare, extreme events and cause significant damage to coastal infrastructure, which is often exacerbated by soil instability surrounding the structures. Simulating tsunamis in a laboratory setting is important to further understand soil instability induced by tsunami inundation processes. Laboratory simulations are difficult because the scale of such processes is very large, hence dynamic similitude cannot be achieved for small-scale models in traditional water-wave-tank facilities.

Survival and cellular immune functions in septic mice treated with growth hormone (GH) and insulin-like growth factor-I (IGF-I).

Objective: GH was used to counteract the catabolic metabolism in critically ill patients until it was demonstrated that administration of GH was associated with an increased morbidity due to uncontrolled infections and sepsis. The immunomodulatory effect of GH and its main mediator IGF-I during systemic inflammation remain to be established. We therefore investigated the effect of GH and IGF-I on cellular immune functions in a murine model of sepsis.

Dopamine affects cellular immune functions during polymicrobial sepsis.

Objective: To determine whether infusion of dopamine modulates cellular immune functions and survival during systemic inflammation.

Design And Setting: Randomized animal study, university research laboratory, Level I trauma center.

Subjects: Male NMRI mice.

Neurologic soft signs in schizophrenic patients treated with conventional and atypical antipsychotics.

Neurologic soft signs (NSS) are considered a somatic feature associated with schizophrenia (DSM-IV) that are present in neuroleptic-treated, as well as untreated or first-episode patients. The aim of this study was to determine the incidence and severity of NSS in groups of schizophrenic patients treated with either a conventional neuroleptic medication, haloperidol (n = 37), or atypical antipsychotic medications, risperidone (n = 19), clozapine (n = 34), and olanzapine (n = 18). NSS were assessed with the Neurological Evaluation Scale (NES), whereas extrapyramidal symptoms (EPS), which occur more commonly with conventional neuroleptic treatment, were evaluated using the Simpson-Angus Scale.