Publications by authors named "M S Esplin"
Article Synopsis
- Spontaneous preterm birth (SPTB) is a major cause of health issues in newborns and can arise from various unknown genetic factors, prompting the need for better understanding through family studies.
- The research utilized the Utah Population Database to identify large families with multiple cases of early SPTB and focused on seven specific pedigrees for genetic analysis, excluding other known causes of preterm birth.
- The study discovered two significant chromosomal regions related to SPTB, particularly in chromosome 8 (8q24.23), suggesting potential genetic markers for this condition.
Article Synopsis
- A study aimed to determine how various risk factors during labor and delivery influence the need for blood transfusions, addressing gaps in existing protocols that don't accurately predict urgency of transfusion needs.
- The research reviewed medical records from nearly 90,000 patients across 18 hospitals over 40 months to identify those who required blood transfusions, particularly focusing on urgent cases.
- Findings included the calculation of odds ratios for needing transfusions based on risk factors, leading to the development of a formula to assess individual risk and optimize blood preparation before childbirth.
Objectives: To determine whether hypertensive disorders of pregnancy (HDP) are associated with maternal coronary artery disease (CAD) and other cardiovascular (CV) diseases within 10-20 years following delivery.
Study Design: Retrospective cohort including all women who delivered ≥ 1 pregnancy ≥ 20 weeks' gestation within a single health system from 1998 to 2008. We excluded those with CV risk factors preceding first delivery or with no follow-up after delivery.
Two-thirds of all human conceptions are lost, in most cases before clinical detection. The lack of detailed understanding of the causes of pregnancy losses constrains focused counseling for future pregnancies. We have previously shown that a missense variant in synaptonemal complex central element protein 2 (SYCE2), in a key residue for the assembly of the synaptonemal complex backbone, associates with recombination traits.
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