Effect of different aspirin doses on arterial thrombosis after canine carotid endarterectomy: a scanning electron microscope and indium-111-labeled platelet study.

Although it is widely accepted that aspirin inhibits platelet aggregation in arterial thrombosis, the appropriate dosage of aspirin remains quite controversial. The purpose of this study was to determine the effect of different doses of aspirin (0.5 mg/kg vs.

Early versus delayed heparin reversal after carotid endarterectomy in the dog. A scanning electron microscopy study.

The present study investigates the hematological reaction to arterial injury during the first 10 minutes after endarterectomy in dogs to determine if heparin reversal during this early period predisposes to thrombus formation. Known platelet physiology would predict that heparinization during this early period would be useful to allow a fibrin-free platelet monolayer to form. After systemic heparinization (145 mu/kg) of the experimental animals, 42 endarterectomies were performed.

The effect of heparin reversal after carotid endarterectomy in the dog. A scanning electron microscopy study.

The purpose of this study was to determine reversal of heparin, immediately after carotid endarterectomy would have an adverse effect on the thrombogenicity of the endarterectomized vessel wall. After systemic heparinization, unilateral common carotid endarterectomies were performed under the operating microscope on 14 dogs. Half of the animals were given protamine sulfate to reverse the heparin.