Accelerated Ten-Gram-Scale Synthesis of One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer 97.

One-component multifunctional sequence-defined ionizable amphiphilic Janus dendrimers (IAJDs) were discovered in our laboratories in 2021 to represent a new class of synthetic vectors for the targeted delivery of messenger RNA (mRNA). They coassemble with mRNA by simple injection of their ethanol solution into a pH 4 acetate buffer containing the nucleic acid into monodisperse dendrimersome nanoparticles (DNPs) with predictable dimensions. DNPs are competitive with 4-component lipid nanoparticles (LNPs), which are used in commercial COVID-19 vaccines, except that IAJDs are prepared in fewer reaction steps than each individual component of the LNPs.

The clinical implications of Porphyromonas gingivalis and its detection methods - a systematic review.

Introduction: Mounting evidence has shown the significant correlation between periodontitis and the development of other comorbidities, such as cardiovascular disease due to periodontopathogenic bacterial migration and colonisation. As the main etiologic agent of periodontitis, the role of Porphyromonas gingivalis (P. gingivalis) has been widely explored as the main culprit and its early detection is crucial to control the exacerbation of diseases.

Risk of colorectal cancer due to Streptococcus gallolyticus: a systematic review.

Introduction: World Health Organization (2019) has declared colorectal cancer (CRC) as the second most common cancer in females and third in males, where the incidence seems to rise year by year. One of the very few potential pathogens specifically associated with malignant colonic diseases is Streptococcus gallolyticus (Sg). Sg is a part of the intestinal flora which formerly known as biotype I of Streptococcus bovis, belongs to Group D streptococci.

Parotid tuberculosis in an immunodeficient patient: A rare case not to be missed.

Extrapulmonary tuberculosis (TB) poses challenges due to its diverse clinical presentation and the complex diagnosis pathway. It includes parotid TB, which has always been underdiagnosed, mismanaged, delayed treatment initiation, and being among the last diagnosis to be made due to the low level of suspicion. Despite living in an endemic area of TB, it is still uncommon for a primary care doctor to propose the diagnosis at the beginning.