Publications by authors named "M S Dolan"
Purpose: Monotherapy with vancomycin or daptomycin remains guideline-based care for methicillin-resistant Staphylococcus aureus bacteremia (MRSA-B) despite concerns regarding efficacy. Limited data support potential benefit of combination therapy with ceftaroline as initial therapy. We present an assessment of outcomes of patients initiated on early combination therapy for MRSA-B.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how resistance to PD-L1 inhibitors affects interferon (IFN) signaling and influences secretory changes in tumor cells.
- It identifies a specific tumor secretome (PTIS) induced by anti-PD-L1 treatment, which can suppress T cell activation and reduce the effectiveness of immune response against tumors.
- The research emphasizes the need for in vivo resistance models to better understand treatment failures, as the tumor's adaptive secretory changes regulated by type I IFNs play a significant role in evading immune attacks.
Tinnitus is a common sensorineural complication that can occur de novo or after cancer treatments involving cisplatin or radiotherapy. Considering the heterogeneous etiology and pathophysiology of tinnitus, the extent to which shared genetic risk factors contribute to de novo tinnitus and cancer treatment-induced tinnitus is not clear. Here we report a GWAS for de novo tinnitus using the UK Biobank cohort with nine loci showing significantly associated variants (p < 5 × 10).
View Article and Find Full Text PDF