Publications by authors named "M S Deshpande"
RNA secondary (2D) structure visualisation is an essential tool for understanding RNA function. R2DT is a software package designed to visualise RNA 2D structures in consistent, recognisable, and reproducible layouts. The latest release, R2DT 2.
View Article and Find Full Text PDFDr. Thomas Francis Jr. was an American physician, virologist, and epidemiologist who was a professor of epidemiology at the University of Michigan from 1941 to 1969.
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- Au nanoparticles (NPs) enhance the field electron emission (FEE) performance of BiS nanorods (NRs), lowering the turn-on field from 3.7 to 2.7 V/μm and increasing maximum emission current density from 138 to 604.8 μA/cm.
- The BiS nanorods, around 120 nm in diameter, form nanoflowers, while 5-10 nm Au NPs are uniformly attached to their surfaces, creating an Au/BiS composite.
- This improvement in FEE is due to reduced work function and more emitting sites provided by the decoration of Au NPs, as confirmed by various analysis techniques like FESEM/TEM, XRD,
Article Synopsis
- - Spirochetes are invasive bacteria linked to diseases like Lyme disease, syphilis, and leptospirosis, using unique periplasmic flagella (PFs) for movement and immune evasion.
- - A specific modification called lysinoalanine (Lal) crosslinking in the PFs is crucial for the motility of certain pathogenic spirochetes and could be targeted for new antimicrobial therapies.
- - Researchers developed a high-throughput screening method that identified two compounds (hexachlorophene and triclosan) that inhibit Lal crosslinking, potentially paving the way for effective treatments against spirochete-related infections.
Longitudinal, non-invasive, in vivo monitoring of therapeutic gene expression is an unmet need for gene therapy (GT). Positron emission tomography (PET) radiotracers designed to bind to therapeutic proteins may provide a sensitive imaging platform to guide treatment response and dose optimization in GT. Herein, we evaluate a novel PET tracer ([F]AGAL) for targeting α-galactosidase A (GLA), an enzyme deficient in Fabry disease.
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