A Lower-Energy Pathway for the Creation of Multifunctional Silicon Suboxide Films.

The possibility of inducing structural crosslinking and densification of plasma-deposited SiO networks by controlling low-energy reaction mechanisms was investigated. For this, films were deposited for 300 s from HMDSO (2%), O (86%) and Ar (12%) mixtures at a working pressure of 15.7 Pa.

cAmbly: A non-toxic cell-penetrating peptide derived from Amblyomin-X with targeted delivery to mitochondrial and cytoplasmic proteins.

The effective delivery of drugs remains a major challenge in the development of new therapeutic molecules. Several strategies have been employed to address this issue, with cell-penetrating peptides (CPPs) standing out due to their ability to traverse cell membranes with minimal cytotoxicity and their relatively straightforward synthesis when conjugated with other molecules. However, while CPPs can successfully enter the cytoplasm, they often lack specificity for particular organelles, leaving target engagement to the drug itself.

Comparing UV and Diesel Cutaneous Damage and Evaluating the Protective Role of a Topical Antioxidant Mixture Containing Vitamin C, E and Ferulic Acid.

Cutaneous tissue is one of the main targets of outdoor stressors, and nowadays, the effect of pollution on skin conditions and premature skin ageing has been well correlated, although the exact effect that different pollutants have on the skin has not been well defined, especially when compared to other stressors. Among the air pollutants, UV radiation and particulate matter (PM) have been found among the most aggressive in terms of skin damage, inducing oxinflammatory responses, promoting degradation of extracellular matrix (ECM) components, and compromising the cutaneous defensive barrier. Topical application of technologies able to prevent oxidative damage is still one of the best approaches to protect our skin, and considering the well-known antioxidant network, application of an antioxidant mixture is more recommended than a single compound.

Nano-ionic Solid Electrolyte FET-Based Reservoir Computing for Efficient Temporal Data Classification and Forecasting.

Physical dynamic reservoirs are well-suited for edge systems, as they can efficiently process temporal input at a low training cost by utilizing the short-term memory of the device for in-memory computation. However, the short-term memory of two-terminal memristor-based reservoirs limits the duration of the temporal inputs, resulting in more reservoir outputs per sample for classification. Additionally, forecasting requires multiple devices (20-25) for the prediction of a single time step, and long-term forecasting requires the reintroduction of forecasted data as new input, increasing system complexity and costs.

Participation in a home visiting program predicted maternal but not child vocabulary diversity: A pragmatic randomized trial in Brazil.

The Criança Feliz (Happy Child) parenting program is a home visiting intervention serving over a million low-income Brazilian families. The current study assessed its longitudinal associations with maternal and child speech and gestures in a subsample (n = 145) from the program's impact evaluation research. We performed a between-participants pragmatic randomized trial.