Publications by authors named "M S Croxson"
Up to 40% of pheochromocytomas (PCCs) and paragangliomas (PGLs) are hereditary. Germline mutations/deletions in fumarate hydratase ( FH ) cause hereditary leiomyomatosis and renal cell carcinoma syndrome which manifests predominantly with FH-deficient uterine/cutaneous leiomyomas and renal cell carcinomas (RCCs)-tumors characterized by loss of immunohistochemical (IHC) expression of FH and/or positive staining for S-(2-succino)-cysteine. Occasional patients develop PCC/PGL.
View Article and Find Full Text PDFAim: To audit short synacthen tests (SSTs) performed at a single laboratory within the greater Auckland area.
Methods: Two hundred and eighty-seven SSTs conducted in 286 individuals between September 2016 and September 2019 were assessed. Test requests were not triaged.
A rare simultaneous manifestation of polyglandular autoimmune syndrome type II.
Endocrinol Diabetes Metab Case Rep
July 2020
Article Synopsis
- - Polyglandular autoimmune syndrome type II is a rare condition involving autoimmune adrenal insufficiency, autoimmune thyroid disease, and/or type-I diabetes, typically developing over several years but can present simultaneously.
- - Patients may also experience other autoimmune diseases, like vitiligo and alopecia, and while coeliac disease is less common in this syndrome, it occurs more often in polyglandular autoimmune syndrome type III.
- - The condition is more prevalent in women and usually appears in individuals during their 30s and 40s, with Addison's disease often preceding or following the onset of other autoimmune diseases, highlighting the importance of screening for coeliac disease in these patients.
A 23-year-old man presenting with florid Cushing's syndrome was found to have high plasma ACTH and very high serum prolactin. Pituitary MRI showed a large invasive macroadenoma. Low-dose cabergoline promptly suppressed both ACTH and prolactin levels within 2 weeks, with unexpected clinical and biochemical hypocortisolism requiring hydrocortisone replacement.
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