Publications by authors named "M S Contigiani"
Medicinal plants have been explored worldwide as potential alternatives for the prevention and treatment of different diseases, including viral infections. Spreng. (Asteraceae) is a native medicinal species widely used in South America.
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- The genus Flavivirus includes around 80 viruses, categorized by their transmission methods, primarily through mosquitoes and ticks, or as insect-specific flaviviruses.
- Researchers investigated insect-specific flaviviruses in Argentina by analyzing the NS5 protein gene in mosquitoes from Córdoba, Chaco, and Tucumán, finding 68 out of 1776 pools positive for viruses like CxFV, KRV, and CFAV.
- A significant presence of CxFV was detected across various mosquito species in northern and central Argentina, with strains showing genetic links to those found in other countries, highlighting potential public health risks due to interactions with pathogenic flaviviruses.
St. Louis encephalitis virus (SLEV) is endemic in the Americas and its transmission networks involve Culex mosquitoes and avian species. In 2015, a human encephalitis outbreak took place in Arizona and California, indicating the re-emergence of this pathogen in the US.
View Article and Find Full Text PDFBackground: Dengue virus (DENV) is considered one of the most important pathogens in the world causing 390 million infections each year. Currently, the development of vaccines against DENV presents some shortcomings and there is no antiviral therapy available for its infection. An important challenge is that both treatments and vaccines must be effective against all four DENV serotypes.
View Article and Find Full Text PDFPixuna virus (PIXV) and Río Negro virus (RNV) are mosquito-borne alphaviruses belonging to the Venezuelan Equine Encephalitis (VEE) complex, which includes pathogenic epizootic and enzootic subtypes responsible for life-threatening diseases in equines. Considering that the first steps in viral infection are crucial for the efficient production of new progeny, the aim of this study was to elucidate the early events of the replication cycle of these two viruses. To this end, we used chemical inhibitors and the expression of dominant-negative constructs to study the dependence of clathrin and endosomal pH on PIXV and RNV internalization mechanisms.
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