The Impact of COVID-19 Social Isolation on Physical Activity and Sedentary Behavior in Brazilian Children and Adolescents.

 To measure the impact of social isolation on physical activities and sedentary behavior in Brazilian children and adolescents. To assess whether factors such as age, gender, days of week, type of housing, and the population of the city also had an impact.  The study was approved by the Medical Ethics Committee, and consent from parents was obtained.

Aberrant DNA methylation of genes regulating CD4+ T cell HIV-1 reservoir in women with HIV.

Background: The HIV-1 reservoir in CD4+ T cells (HR) pose a major challenge to curing HIV, with many of its mechanisms still unclear. HIV-1 DNA integration and immune responses may alter the host's epigenetic landscape, potentially silencing HIV-1 replication.

Methods: This study used bisulphite capture DNA methylation sequencing in CD4+ T cells from the blood of 427 virally suppressed women with HIV to identify differentially methylated sites and regions associated with HR.

Are More Young, Western Patients Also Developing Hepatocellular Carcinoma?

Background: While the incidence of early-onset cancers is rising, it is unclear whether this is the case for early-onset hepatocellular carcinoma (eHCC). Even the definition of eHCC remains unclear. This study was designed to identify an age cutoff for eHCC and to explore trends in its incidence, clinical presentation, surgical outcomes, and long-term survival compared to typical-onset HCC (tHCC).

Visual Assessment of Facial Differences in Patients Reconstructed With Ocular Prostheses: A Web-Based Survey.

Background: This study intends to determine the visual recognition of facial differences between patients reconstructed with ocular prostheses and its similarities or differences to the contralateral unaffected eye. The authors hypothesize that a prosthetic eye is an indistinguishable replacement for the appearance of an original eye.

Methods: This is a randomized, local, photo-based survey.

Periacetabular Osteotomy with Concomitant Hip Arthroscopy Shows Comparable Outcomes Compared to Isolated Hip Arthroscopy with Capsular Plication in Borderline Dysplastic Hips: A Propensity-Matched Study.

Purpose: To compare minimum 2-year outcomes of concomitant hip arthroscopy (HA) with periacetabular osteotomy (PAO) versus isolated HA with capsular plication in patients with borderline hip dysplasia (BHD).

Methods: Data were retrospectively reviewed for patients who underwent surgery for femoroacetabular impingement in the setting of BHD between September 2008 and December 2021. Included patients had preoperative and minimum 2-year patient reported outcomes scores (PROs).