Publications by authors named "M S Cheon"
Epigenetic clocks have been developed to track both chronological age and biological age, which is defined by physiological biomarkers and the risk of adverse health outcomes. Epigenetic age acceleration (EAA) has been found to predict various diseases, aging-related factors, and mortality. However, epigenetic clocks have predominantly been developed with individuals of European or Hispanic ancestry, and their association with health outcomes and environmental factors has not been sufficiently assessed in East Asian populations.
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- Polygenic risk scores (PRS) and rare genetic variant screening are crucial for predicting cancer risk, but integrating these two for accurate assessments is challenging.
- A study analyzed a large dataset focusing on breast and prostate cancers and introduced an Expanded PRS (EPRS) approach, which allows for better risk evaluation by linking both common and rare genetic variants.
- The findings indicate that individuals with high PRS and rare, high-impact variants face significantly higher cancer risks, suggesting that this EPRS method could improve risk stratification and may be useful for other cancer types in future research.
Article Synopsis
- Understanding the interplay of genes over time is crucial for diagnosing and treating diseases, as it reveals the underlying regulatory mechanisms of biological processes.* -
- Generative adversarial networks (GANs) are used to enhance biological data, helping to uncover hidden gene expression profiles during specific processes, which can lead to identifying key regulatory genes.* -
- In a study of cocaine addiction using mice, two genes (Alcam and Celf4) were identified as significant intermediates correlated with addiction behavior, demonstrating the effectiveness of combining GAN-WGCNA analysis with time-series gene expression data.*
Article Synopsis
- - The study investigated if a shorter, high-dose rifampicin treatment for tuberculosis is as effective as the standard 6-month regimen.
- - A total of 76 participants were enrolled, but the results showed a higher percentage of unfavorable outcomes in the investigational group compared to the control group, indicating the shorter regimen was not non-inferior.
- - Despite failing to prove non-inferiority, the shorter regimen did have a similar safety profile compared to the standard treatment.
Article Synopsis
- The first mirror in fusion plasmas reflects light to the diagnostic system and is made from silicon carbide (SiC) for its strength and radiation resistance.
- A device was developed to measure the reflectivity of the SiC mirror at specific angles using a hollow cathode lamp and a dedicated VUV spectrometer.
- Experimental results showed that the reflectivity values of SiC were influenced by both the oxidation layer on the surface and the incidence angle of the VUV light.