Publications by authors named "M S Chaudhry"
Brucellosis is a disease that poses a higher risk of transmission to animals and people who have close interactions with them, such as farmers. Therefore, the present study was designed to determine the seroprevalence of bovine brucellosis and associated risk factors in Kasur, Punjab, Pakistan. One hundred pooled milk samples from 100 smallholder mixed herds of cows and buffaloes with a total study population of 425 animals (277 cattle and 148 buffalos) with a range of up to seven animals in each herd were collected and tested through a milk ring test (MRT).
View Article and Find Full Text PDFLight-Chain Myeloma Presented as Osseus Tumors: A Case Report.
J Investig Med High Impact Case Rep
December 2024
Article Synopsis
- Light-chain multiple myeloma (LCMM) is a rare type of cancer involving plasma cells, often related to kidney issues and bone damage, but cases presenting as bone tumors are uncommon.
- A 63-year-old male presented with rib pain, and imaging revealed an isolated tumor in his eighth rib along with multiple lytic bone lesions elsewhere, which were confirmed to be caused by plasma cells producing kappa light chains.
- Treatment with daratumumab, bortezomib, lenalidomide, and dexamethasone led to notable improvement, highlighting the diagnostic challenges of LCMM and the need to consider it in bone tumor evaluations.
This article discusses the growing burden of smog in Pakistan, tracing its origins to vehicular emissions, industrial pollutants, and agricultural practices. It highlights current national initiatives and advocates for enhanced government interventions to mitigate smog's adverse effects on ocular health. It also emphasizes the need for collective action to safeguard ocular health amid rising smog pollution in Pakistan.
View Article and Find Full Text PDFInterferon-alpha has activity against multiple myeloma. Modakafusp alfa is an immunocytokine comprising two attenuated interferon-alpha2b molecules and an anti-CD38 IgG4 antibody, targeting delivery of interferon-alpha to CD38+ immune and myeloma cells. This phase I/II trial (NCT03215030) enrolled patients with relapsed/refractory multiple myeloma with ≥3 prior lines of treatment and refractory to or intolerant of ≥1 proteasome inhibitor and ≥1 immunomodulatory drug.
View Article and Find Full Text PDFArticle Synopsis
- Giant cell tumour of bone (GCTB) is a rare benign tumor that mainly affects young adults (ages 20-40) and is classified as an intermediate malignant tumor by the WHO, with its pathology linked to the expression of RANKL.
- A study conducted over 36 months at a military hospital investigated the effects of preoperative denosumab therapy on GCTB patients, measuring pain and functional status before and after treatment.
- Results showed significant improvement in pain and function, shifting the intended surgical approach from more invasive procedures like joint resection to less aggressive options such as intralesional curettage post-denosumab therapy.