Publications by authors named "M S Chambers"
Low-grade inflammation and pathological endochondral ossification are key processes underlying the progression of osteoarthritis, the most prevalent joint disease worldwide. In this study, we employed a multi-faceted approach, integrating publicly available datasets, analyses, experiments and models to identify new therapeutic candidates targeting these processes. Data mining of transcriptomic datasets identified EPHA2, a receptor tyrosine kinase associated with cancer, as being linked to both inflammation and endochondral ossification in osteoarthritis.
View Article and Find Full Text PDFPrevalence of and spp. in populations of cats from shelters and research colonies, in two endemic regions of eastern Australia.
Curr Res Parasitol Vector Borne Dis
October 2024
There is a paucity of available prevalence data for key parasite species and genera infecting cats in Australia. The present study aimed to determine the prevalence of key parasites infecting cats in Australia, namely the feline heartworm, , and the cestodes and spp. The prevalence of these parasites was assessed in cat populations in five separate locations of eastern Australia and within two geographical regions: humid subtropical and oceanic.
View Article and Find Full Text PDFArticle Synopsis
- The study assessed the effectiveness of two types of ivermectin in killing wild-caught Anopheles mosquitoes in cattle and buffalo on Sumba Island, Indonesia, finding cattle had higher blood levels of the drug.
- Nine species of Anopheles mosquitoes were tested for susceptibility to ivermectin, with varying degrees of lethality, revealing that long-lasting ivermectin outperformed the standard formulation, especially in cattle.
- Buffalo were found to attract mosquitoes more than cattle, horses, and humans, indicating they might need higher doses of long-lasting ivermectin to match the effectiveness seen in cattle, highlighting the potential of ivermectin as a livestock treatment for malaria control in Southeast Asia.
Inorganic fillers play an important role in improving the ionic conductivity of solid composite electrolytes (SCEs) for Li-ion batteries. Among inorganic fillers, perovskite-type lithium lanthanum titanate (LLTO) stands out for its high bulk Li conductivity on the order of 10 S cm at room temperature. According to a literature survey, the optimal LLTO filler should possess the following characteristics: i) a single-crystal structure to minimize grain boundaries; ii) a small particle size to increase the filler/polymer interface area; iii) a 1D morphology for efficient interface channels; and iv) cubic symmetry to facilitate rapid bulk Li diffusion within the filler.
View Article and Find Full Text PDFProteogenomic profiling of acute myeloid leukemia to identify therapeutic targets.
Expert Rev Proteomics
November 2024
Article Synopsis
- Acute myeloid leukemia (AML) is a serious blood cancer with a complex nature, making it challenging to find effective treatments despite advancements in genomic profiling.
- Combining genomic and proteomic profiling (proteogenomic profiling) can help understand the mechanisms behind AML and identify new therapeutic targets and biomarkers for treatment response.
- While proteogenomic profiling shows promise and progress is being made towards clinical application, there still needs to be standardization in protocols to make these tests widely used in hospitals.