Publications by authors named "M S Castilho"
Soybean β-Conglycinin and Cowpea β-Vignin Peptides Inhibit Breast and Prostate Cancer Cell Growth: An In Silico and In Vitro Approach.
Foods
November 2024
B-cell lymphoma 2 protein (Bcl-2) is an important regulator of cell apoptosis. Inhibitors that mirror the structural domain 3 (BH3) of Bcl-2 can activate apoptosis in cancer cells, making them a promising target for anticancer treatment. Hence, the present study aimed to investigate potential BH3-mimetic peptides from two vicilin-derived legume proteins from soybean and cowpea bean.
View Article and Find Full Text PDFA novel approach merging melt electrowriting (MEW) with matched die thermoforming to achieve scaffolds with micron-sized curvatures (200 - 800 µm versus 1000 µm of mandrel printing) for in vitro modeling of the kidney proximal tubule (PT) is proposed. Recent advances in this field emphasize the relevance of accurately replicating the intricate tissue microenvironment, particularly the curvature of the nephrons' tubular segments. While MEW offers promising capabilities for fabricating highly and porous precise 3D structures mimicking the PT, challenges persist in approximating the diameter of tubular scaffolds to match the actual PT.
View Article and Find Full Text PDFThis is the first reported case of Bertiella mucronata infection in a black-and-gold howler monkey (Alouatta caraya) in Brazil. The present study confirms the widespread of B. mucronata in South America and suggest that black-and-gold howler monkeys may serve as viable reservoirs for B.
View Article and Find Full Text PDFSafety of Hepatitis B Virus Screening in Blood Donors from the Hospital Foundation of Hematology and Hemotherapy of the State of Amazonas (HEMOAM) in the Brazilian Amazon.
Viruses
October 2024
Background: Hepatitis B is an infectious disease of worldwide importance and of great interest to transfusion medicine. The Amazon region has areas of high endemicity, outlining a worrying scenario for transfusion and epidemiological safety.
Objective: To analyze the profiles of serological and molecular markers for HBV of blood donors from HEMOAM.
Article Synopsis
- Current 3D silk fibroin scaffold creation methods struggle with unwanted molecular rearrangement, leading to brittleness and poor organization at various scales.
- A novel process using electrowriting and sodium dihydrogen phosphate allows for controlled gelation and formation of stable structures with both β-sheet and random coil conformations, while achieving customizable architectures.
- The resulting scaffolds support the growth and alignment of renal epithelial and endothelial cells, promoting healthy tissue development, which shows promise for future tissue engineering applications.