A Comprehensive Review of the Physical Examination for the Biceps-Labrum Complex of the Shoulder.

Biceps-labrum complex (BLC) disease is a well-established pain generator in the shoulder. Despite its ubiquity, BLC disease continues to pose a diagnostic challenge for orthopaedic surgeons. The use of magnetic resonance imaging and glenohumeral arthroscopy in the diagnosis of BLC disease has proven to be inadequate when performed independently.

Long-term prescription opioid use following surgery in the US (2017-2022): a population-based study.

Background: Over the last decade, numerous efforts have been made to combat the opioid crisis globally. The impact of these strategies has not been adequately measured and may differ across populations depending on baseline risk. We compared changes in long-term prescription opioid use following surgery within a national US cohort, between 2017 and 2022.

Consumption of antimicrobials for use in food-producing animals in New Zealand, a measure of progress in reduction from 2015 to 2022.

Aims: To describe progress in the reduction of the consumption of antimicrobial drugs by food-producing animals in New Zealand to 2022 and to identify the animal production sectors where progress has been greatest, and those where opportunities remain.

Methods: Data were sourced from official government and industry reports to update previous estimates of consumption (as sales) of antimicrobial products applied to food-producing animals in New Zealand, European countries and the USA. Antimicrobial consumption (AMC) was estimated based on the amount of active ingredient sold, per kg of animal biomass standardised to the probable weight at time of treatment or lifetime mean weight but not slaughter weight (population correction unit; PCU).

Repair Fails More Frequently Than Reconstruction in Acute Posterolateral Corner Knee Injuries: A Systematic Review of Outcomes Following Surgical Management.

Purpose: To synthesize the current literature on posterolateral corner (PLC) reconstruction and repair, focusing on a comparison of surgical techniques and outcomes based on injury chronicity in the setting of sports-related ligament tears.

Methods: A systematic review of the literature, including queries of the PubMed/MEDLINE, Embase, and Cochrane Library databases, was performed in March 2024. Studies were included if they were of Level IV evidence or greater, reported PLC reconstruction or repair outcomes, and had a minimum 2-year follow-up.

Toward Dose Prediction at Point of Design.

Human dose prediction (HDP) is a useful tool for compound optimization in preclinical drug discovery. We describe here our exclusively in silico HDP strategy to triage compound designs for synthesis and experimental profiling. Our goal is a model that provides a preliminary estimate of the dose for a given exposure target based on chemical structure.