Publications by authors named "M S Boyne"

Sports physiotherapists and coaches are tasked with evaluating the movement quality of athletes across the spectrum of ability and experience. However, the accuracy of visual observation is low and existing technology outside of expensive lab-based solutions has limited adoption, leading to an unmet need for an efficient and accurate means to measure static and dynamic joint angles during movement, converted to movement metrics useable by practitioners. This paper proposes a set of pose landmarks for computing frequently used joint angles as metrics of interest to sports physiotherapists and coaches in assessing common strength-building human exercise movements.

View Article and Find Full Text PDF

Backgrounds & Aims: Childhood malnutrition is a major global health problem with long-term sequelae, including non-communicable diseases (NCDs). Mechanisms are unknown but may involve metabolic programming, resulting from "short-term" solutions to optimise survival by compromising non-priority organs. As key players in lipid metabolism, desaturases have been shown to be predictive of NCDs.

View Article and Find Full Text PDF

Nutritional rehabilitation during severe acute malnutrition (SAM) aims to quickly restore body size and minimize poor short-term outcomes. We hypothesized that faster weight gain during treatment is associated with greater cardiometabolic risk in adult life. Anthropometry, body composition (DEXA), blood pressure, blood glucose, insulin and lipids were measured in a cohort of adults who were hospitalized as children for SAM between 1963 and 1993.

View Article and Find Full Text PDF

The NIH Toolbox Cognitive Battery (NIHTB-CB) was developed as a common-metric, computerized cognitive screener for research. Although extensively normed and validated in Americans of different ethnicities, there is little data on how generalizable such results would be when used outside of the United States. The objective of this study was to assess measurement invariance (MI) of the NIHTB-CB across Jamaican and African-American samples and determine appropriateness of comparisons across groups.

View Article and Find Full Text PDF
Article Synopsis
  • Recent studies show that infusion therapies using immune-modifying nanoparticles (ONP-302) can boost the immune response against tumors, specifically in a small group of patients.
  • The altered dosing of ONP-302 leads to enhanced tumor immunity by targeting myeloid cells, which helps to decrease tumor growth and activate natural killer (NK) cells via the cGAS/STING pathway.
  • Additionally, ONP-302 treatment raises PD-1/PD-L1 levels in the tumor environment, improving the effectiveness of anti-PD-1 therapy in aggressive melanoma models that usually resist this treatment.
View Article and Find Full Text PDF