Validation of an UPLC-PDA Method for the Simultaneous Quantification of Phenol and Iomeprol in a Sterile Parenteral Preparation Used for Coeliac Plexus Block, and Its Application to a Pharmaceutical Stability Study.

A commonly applied analgesic therapy for patients with severe abdominal pain due to cancer-related pain in the upper abdomen, is coeliac plexus neurolysis (CPN). Herein, a combination product of phenol and an iodine contrast agent are injected simultaneously. The chemical stability of such a combination product is unknown, and no chromatographic method is yet available that describes the simultaneous quantification of phenol and iomeprol.

Microbiome structure and function in parallel full-scale aerobic granular sludge and activated sludge processes.

Aerobic granular sludge (AGS) and conventional activated sludge (CAS) are two different biological wastewater treatment processes. AGS consists of self-immobilised microorganisms that are transformed into spherical biofilms, whereas CAS has floccular sludge of lower density. In this study, we investigated the treatment performance and microbiome dynamics of two full-scale AGS reactors and a parallel CAS system at a municipal WWTP in Sweden.

3D-printed and conventional provisional single crown fabrication on anterior implants: A randomized clinical trial.

Objectives: The present study aims to compare provisional single crowns on anterior implants made using conventional PMMA and 3D-printed workflows. The study assessed the occurrence of failures, color variation, signs of early deterioration, operating time, and patients' satisfaction with the treatment through a randomized controlled trial.

Methods: This study was conducted as a randomized controlled trial, following the SPIRIT and CONSORT guidelines.

Case study of aerobic granular sludge and activated sludge-Energy usage, footprint, and nutrient removal.

This study demonstrates a comparison of energy usage, land footprint, and volumetric requirements of municipal wastewater treatment with aerobic granular sludge (AGS) and conventional activated sludge (CAS) at a full-scale wastewater treatment plant characterized by large fluctuations in nutrient loadings and temperature. The concentration of organic matter in the influent to the AGS was increased by means of hydrolysis and bypassing the pre-settler. Both treatment lines produced effluent concentrations below 5 mg BOD L , 10 mg TN L , and 1 mg TP L , by enhanced biological nitrogen- and phosphorus removal.

Safety and cross-variant immunogenicity of a three-dose COVID-19 mRNA vaccine regimen in kidney transplant recipients.

Background: The immunogenicity of a two-dose mRNA COVID-19 vaccine regimen is low in kidney transplant (KT) recipients. Here, we provide a thorough assessment of the immunogenicity of a three-dose COVID-19 vaccine regimen in this population.

Methods: We performed a prospective longitudinal study in sixty-one KT recipients given three doses of the BNT162b2 COVID-19 vaccine.