Science behind cisplatin-induced nephrotoxicity in humans: a clinical study.

Objective: To investigate the relationship between serum electrolyte changes and cisplatin induced nephrotoxicity.

Methods: We collected data from 18 patients undergoing cisplatin chemotherapy including serum electrolytes, creatinine, blood urea nitrogen (BUN) and urine potassium, sodium and pH levels before and after the cisplatin chemotherapy. All the patients had cancer and were treated with 40-50 mg/day cisplatin.