Publications by authors named "M S B Jeffrey"
A woman in her early 20s presented with a huge pedunculated tumour of the vulva which had progressively increased in size over the course of 10 years. Clinical examination revealed a pedunculated solid mass arising from the right labia majora measuring 15×15 cm. CT scan showed a multilobulated mass arising from the right round ligament suggestive of an extrauterine fibroid.
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- The study focuses on evaluating the heterogeneous treatment effect (HTE) of benzene exposure on childhood acute myeloid leukemia (AML) using three machine learning algorithms: causal random forest (CRF), causal Bayesian additive regression trees (CBART), and causal rule ensemble (CRE).
- All three algorithms showed minimal differences in their predicted average treatment effects and regression coefficients, but CRF was more efficient in computational time and capable of handling both continuous and binary treatment variables.
- The research also explores the effects of adding noise and outliers in data analysis with CRF and provides guidelines for researchers on using these algorithms for environmental health studies and pollutant exposure assessments.
Several known biomarkers have been used to understand the physiological responses of humans to various short and long-term interventions such as exercise or dietary interventions. However, little exploratory work has been conducted to identify novel biomarkers in human saliva that could enable non-invasive physiological research to understand acute responses to interventions such as reducing sedentary time. The purpose of this study was to identify novel biomarkers in the saliva (cytokines, growth factors and vascular factors) that respond to prolonged (4 hours) and interrupted sitting (4 hours of sitting interrupted by 3 minutes of walking at 60% of maximal heart rate every 27 minutes) in young, healthy males and females.
View Article and Find Full Text PDFMacrophage responses to activation are fluid and dynamic in their ability to respond appropriately to challenges, a role integral to host defence. While bacteria can influence macrophage differentiation and polarization into pro-inflammatory and alternatively activated phenotypes through direct interactions, many questions surround indirect communication mechanisms mediated through secretomes derived from gut bacteria, such as lactobacilli. We examined effects of secretome-mediated conditioning on THP-1 human monocytes, focusing on the ability of the Lacticaseibacillus rhamnosus R0011 secretome (LrS) to drive macrophage differentiation and polarization and prime immune responses to subsequent challenge with lipopolysaccharide (LPS).
View Article and Find Full Text PDFScope: Gastro-AD (GAD) is a soy flour derived product that undergoes an industrial fermentation with Lactobacillus delbrueckii R0187 and has demonstrated clinical effects in gastroesophageal reflux and peptic ulcer symptom resolution. The aim of this study is to describe and link GAD's metabolomic profile to plausible mechanisms that manifest and explain the documented clinical outcomes.
Methods And Results: H NMR spectroscopy with multivariate statistical analysis is used to characterize the prefermented soy flour and GAD products.