Identification of potent TMPRSS4 inhibitors through structural modeling and molecular dynamics simulations.

TMPRSS4, a transmembrane serine protease type II, is associated with various pathological illnesses. It has been found to activate SARS-CoV-2, enhance viral infection of human small-intestinal enterocytes and is overexpressed in different types of cancers. Therefore, this study aims to disover potential TMPRSS4 inhibitors that have better binding affinity than the approved inhibitors: 2-hydroxydiarylamide and tyroserleutide.

Automated compilation of Urdu poetry handwritten image datasets for optical character recognition.

Optical character recognition (OCR) is vital in digitizing printed data into a digital format, which can be conveniently used for various purposes. A significant amount of work has been done in OCR for well-resourced languages like English. However, languages like Urdu, spoken by a large community, face limitations in OCR due to a lack of resources and the complexity and diversity of handwritten scripts.

Tear film parameters in females with thyroid eye disease and diabetes: an observational study.

Objectives: To assess different tear film parameters in female patients with thyroid eye disease and diabetes using a single portable device.

Methods: The observational study was conducted at the College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia, from January 12 to April 28, 2022, and comprised women patients with thyroid eye disease in group A, women patients with diabetes in group B, and healthy controls in group C. The sample size was determined with a confidence level of 80% and a significance of 0.

Protective roles of herbal teas against the toxicity of Bisphenol A on morphometry of uterus and improving murine reproductive health (incomplete title and amended by the EIC).

The purpose of the current study was to investigate the potential ameliorating murine reproductive effects of herbal tea extracts against bisphenol A-induced (BPA) cytotoxicity. A comparative study was applied among red, green and blue teas in mice groups. Samples were coded as RTE, GTE and BTE groups, respectively.