Causal relationship between drug target genes of LDL-cholesterol and coronary artery disease: drug target Mendelian randomization study.

Background: High LDL-cholesterol (LDL-C) is a well-known risk factor for coronary artery disease (CAD). PCSK9, HMGCR, NPC1L1, ACLY, and LDLR gene have been reported as lipid lowering drug genes related to LDL-C lowering. However relevant Asian studies were rare.

Phase 2 study of neoadjuvant durvalumab plus docetaxel, oxaliplatin, and S-1 with surgery and adjuvant durvalumab plus S-1 for resectable locally advanced gastric cancer.

Background: Based on the phase 3 PRODIGY study, neoadjuvant docetaxel, oxaliplatin, and S-1 (DOS) have emerged as a viable treatment option for Asian patients with resectable locally advanced gastric cancer (LAGC). This phase 2 study evaluated the efficacy and safety of combining neoadjuvant durvalumab with DOS, followed by surgery and adjuvant durvalumab plus S-1 chemotherapy, for resectable LAGC.

Methods: Patients with LAGC with cT2/3N+or cT4Nany tumors were enrolled in this study.

Blood TCTP as a potential biomarker associated with immunosuppressive features and poor clinical outcomes in metastatic gastric cancer.

Background: No established biomarker exists for specific myeloid cell populations or in gastric cancer. This study aimed to explore the prognostic and immunological relevance of plasma translationally controlled tumor protein (TCTP) in patients with advanced gastric cancer treated with an immune checkpoint inhibitor and/or cytotoxic chemotherapy.

Methods: Plasma samples were prospectively collected from the cohorts of patients with gastric cancer treated with first-line fluoropyrimidine plus platinum chemotherapy (n=143, cohort 1) and third-line nivolumab (n=165, cohort 2).

Efficient biological funneling of lignin into 2-pyrone-4,6-dicarboxylic acid via electrocatalytic depolymerization and genetically engineered Pseudomonas putida KT2440.

Lignin has been an abundant biomass resource with remarkable potential to produce value-added chemicals. The comprehensive process from lignin degradation to the biological conversion of its monomers remains a challenge for demonstrating the industrial applicability of lignin refinery. Herein, Pseudomonas putida KT-PDCV overexpressing homologous vanillate-O-methylase (VanAB) could efficiently produce 2-pyrone-4,6-dicarboxylic acid (PDC) from lignin-derived compounds (LDC), including S-unit monomers (e.

Enhanced phytoremediation and biosorption of cationic methylene blue dye by ATCC 26774.

In this study, the enhancement of the phytoremediation and biosorption properties of the cationic dye methylene blue using ATCC 26774 were investigated. Inoculation with ATCC 26774 increased the length of roots by 82.3% and stems by 37.