Publications by authors named "M Ryks"
Objective: Chronic constipation (CC) more frequently affects the elderly; pelvic floor dysfunction (PFD) may confuse the appraisal of the pathophysiology of CC. The aim was to characterize colonic transit (CT) in elderly with CC with/without PFD.
Design: We conducted retrospective medical records review of 191 patients ≥ 65 years who underwent scintigraphic CT for assessing CC.
Background: Colonic transit (CT) measured by validated scintigraphy using In-labeled activated charcoal particles is summarized using geometric center (GC) of isotopic distribution in four colonic regions and stool at 24 and 48 h. Diagnosis of rapid CT is currently based on GC24 ≥4.4 in females and >4.
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- This study investigates the physiological and molecular characteristics of postinfection irritable bowel syndrome (PI-IBS) in comparison to healthy individuals, focusing on factors like gene expression, gut bacteria, and metabolites.
- Fifty-one PI-IBS patients and 39 healthy volunteers completed various assessments, revealing increased colonic permeability in PI-IBS patients, along with significant differences in gene expression and metabolite presence.
- Key findings include elevated levels of certain metabolites like N-acetylputrescine, which are linked to increased colonic permeability, worse diarrhea, and variations based on sex, helping to better understand PI-IBS's impact.
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- The study investigated how ondansetron affects patients with diabetic gastroenteropathy (DGE) compared to a placebo.
- Patients took ondansetron or a placebo for 4 weeks, and their symptoms and gastric emptying were monitored through various methods.
- Ondansetron reduced feelings of fullness and belching during lipid infusions but did not significantly affect daily symptoms compared to placebo, although some patients showed potential for symptom improvement when ondansetron was effective during the lipid challenge.
Satiation is the physiologic process that regulates meal size and termination, and it is quantified by the calories consumed to reach satiation. Given its role in energy intake, changes in satiation contribute to obesity's pathogenesis. Our study employed a protocolized approach to study the components of food intake regulation including a standardized breakfast, a gastric emptying study, appetite sensation testing, and a satiation measurement by an test.
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