Publications by authors named "M Ruospo"
Interventions for preventing the progression of autosomal dominant polycystic kidney disease.
Cochrane Database Syst Rev
October 2024
Article Synopsis
- Autosomal dominant polycystic kidney disease (ADPKD) is a major hereditary kidney disease, with traditional treatment focusing on symptom management rather than disease progression.
- Recent advancements in understanding the disease's mechanisms have led to new medications aimed at halting its progression, though their effectiveness for all patients remains uncertain.
- The review aims to assess the safety and impact of these interventions using patient-focused outcomes while analyzing data from various clinical studies and trials.
Article Synopsis
- Diabetes significantly increases the risk of chronic kidney disease (CKD) and cardiovascular issues, with about one in three adults with diabetes also having CKD.
- SGLT2 inhibitors show promise in improving kidney and heart health for individuals with CKD and diabetes, but ongoing research is needed to evaluate their effectiveness.
- This review examines randomised controlled trials of SGLT2 inhibitors to provide a comprehensive assessment of their benefits and risks for patients with CKD and diabetes.
Anticoagulation for people receiving long-term haemodialysis.
Cochrane Database Syst Rev
January 2024
Background: Haemodialysis (HD) requires safe and effective anticoagulation to prevent clot formation within the extracorporeal circuit during dialysis treatments to enable adequate dialysis and minimise adverse events, including major bleeding. Low molecular weight heparin (LMWH) may provide a more predictable dose, reliable anticoagulant effects and be simpler to administer than unfractionated heparin (UFH) for HD anticoagulation, but may accumulate in the kidneys and lead to bleeding.
Objectives: To assess the efficacy and safety of anticoagulation strategies (including both heparin and non-heparin drugs) for long-term HD in people with kidney failure.
Dietary phosphorus restrictions are usually recommended for people on haemodialysis, although its impact on patient-relevant outcomes is uncertain. We aimed to evaluate the association between total phosphorus intake and its sources with mortality in haemodialysis. Phosphorus intake was ascertained within the DIET-HD study in 8110 adults on haemodialysis.
View Article and Find Full Text PDFHypoxia-inducible factor stabilisers for the anaemia of chronic kidney disease.
Cochrane Database Syst Rev
August 2022
Background: Anaemia occurs in chronic kidney disease (CKD) and is more prevalent with lower levels of kidney function. Anaemia in CKD is associated with death related to cardiovascular (CV) disease and infection. Established treatments include erythropoiesis-stimulating agents (ESAs), iron supplementation and blood transfusions.
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