Loneliness and biomarkers of Alzheimer's disease, axonal damage, and astrogliosis: A coordinated analysis of two longitudinal cohorts.

Objectives: Loneliness is associated with an elevated risk of dementia. There is mixed evidence from imaging studies on whether loneliness is associated with neuropathology in dementia-free adults. This study tests whether loneliness is associated with plasma neurobiomarkers of amyloid (Aβ42/Aβ40), phosphorylated tau 181 (pTau181), neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP) and imaging measures of amyloid and tau.

A Meta-analysis of Loneliness and Risk of Dementia using Longitudinal Data from >600,000 Individuals.

Loneliness is one critical risk factor for cognitive health. Combining data from ongoing aging studies and the published literature, we provided the largest meta-analysis on the association between loneliness and dementia ( = 21 samples, = 608,561) and cognitive impairment ( = 16, = 103,387). Loneliness increased risk for all-cause dementia (HR = 1.

Coping Styles as Mediators Between Purpose in Life and Cognitive Function: A Longitudinal Study.

This study tests associations between purpose in life and coping, and whether coping mediates the association between purpose and cognitive function. Longitudinal data from the Midlife Development in the United States (MIDUS) study were used to investigate associations between purpose at MIDUS I and coping at MIDUS II ( = 2386). Emotion-focused and problem-focused coping were tested as mediators between purpose and cognitive function (memory, executive function, global cognition) at MIDUS III.

Meaning in life and neurobiomarkers of brain health in the UK Biobank.

This study examines meaning in life and four neurobiomarkers implicated in dementia risk: amyloid-β 42 to 40 ratio, phosphorylated tau-181, neurofilament light, and glial fibrillary acidic protein. Adults without dementia (= 1150; = 59.89) from the UK Biobank reported their meaning in life; neurobiomarkers were assayed twice Meaning in life was unrelated to the biomarkers at either assessment (βs range -0.