Publications by authors named "M Ruchala"
Elimination of oral foci of infection might lead to clinical improvement of Graves' orbitopathy.
Graefes Arch Clin Exp Ophthalmol
January 2025
Purpose: Graves' disease (GD) and Graves' orbitopathy (GO) are multifactorial disorders with links to the gut microbiome and autoimmunity. It is observed that patients with GD exhibit altered gut microbiome diversity. However, little is known about the role of oral microbiota in GD and GO.
View Article and Find Full Text PDFIntroduction And Objectives: Isolated hypogonadotropic hypogonadism (IHH) may be associated with pituitary gland and olfactory system disorders. We aimed to correlate findings of Magnetic Resonance Imaging (MRI) of the pituitary gland and olfactory system in IHH patients with the patients' olfactory phenotype.
Patients And Methods: The present research was a single-center retrospective case-control study.
Background: Saliva could be an attractive alternative to blood for assessing thyroid hormonal function.
Objectives: Our goal was to determine if the levels of thyroid hormones in saliva can accurately reflect a person's thyroid status and if they consistently correlate with the levels of the same hormones in the blood.
Design: We conducted a cross-sectional study.
Article Synopsis
- The study examines the potential of serum CD5L, a liver-derived protein, as an additional biomarker for assessing thyroid hormone (TH) status during pregnancy, where routine markers may change.
- Researchers developed a sensitive assay to measure CD5L levels and investigated factors that might influence its concentrations, finding that it remained stable and unaffected by circadian rhythms or liver disease.
- Results showed that CD5L positively correlated with free triiodothyronine (fT3) and trace elements like selenium and copper in pregnant women, suggesting its potential usefulness as a reliable TH status indicator, especially in pregnancy and thyroid-related conditions.
Article Synopsis
- * A study analyzed medical records between January 2015 and December 2022, finding that 77.36% of preoperative male patients had HH, but this decreased to 58.49% post-surgery, along with significant increases in testosterone levels.
- * The research suggests that younger patients with macroadenomas and hyperprolactinemia are more prone to preoperative HH, and about 30% may see hormone normalization after neurosurgical intervention.