Essential role of the mitochondrial Na/Ca exchanger NCLX in mediating PDE2-dependent neuronal survival and learning.

Impaired phosphodiesterase (PDE) function and mitochondrial Ca (i.e., [Ca]m) lead to multiple health syndromes by an unknown pathway.

Injuries From Explosions: More Differences Than Similarities Between Various Types.

Objective: To compare injury patterns of different types of explosions.

Methods: A retrospective study of 4508 patients hospitalized due to explosions recorded in the Israel National Trauma Registry between January 1997 and December 2018. The events were divided into 4 groups: terror-related, war-related, civilian intentional explosions, and civilian unintentional explosions.

ASIC1a senses lactate uptake to regulate metabolism in neurons.

Lactate is a major metabolite largely produced by astrocytes that nourishes neurons. ASIC1a, a Na and Ca-permeable channel with an extracellular proton sensing domain, is thought to be activated by lactate through chelation of divalent cations, including Ca, Mg and Zn, that block the channel pore. Here, by monitoring lactate-evoked H and Ca transport in cultured mouse cortical and hippocampal neurons, we find that stereo-selective neuronal uptake of L-lactate results in rapid intracellular acidification that triggers H extrusion to activate plasma membrane ASIC1a channels, leading to propagating Ca waves into the cytosol and mitochondria.

Introduction of hospital quality measures may lead to a temporary decrease in patient outcomes.

Objectives: To analyse the impact of hospital quality indicators on hip fracture mortality in Israel.

Study Design: A retrospective observational study.

Methods: Data were collected on all patients aged ≥65 years with an isolated hip fracture in the years 2010-2016 from the Israel's National Trauma Registry.

COVID-19 Changed the Injury Patterns of Hospitalized Patients.

Introduction: Injury patterns are closely related to changes in behavior. Pandemics and measures undertaken against them may cause changes in behavior; therefore, changes in injury patterns during the coronavirus disease 2019 (COVID-19) outbreak can be expected when compared to the parallel period in previous years.

Study Objective: The aim of this study was to compare injury-related hospitalization patterns during the overall national lockdown period with parallel periods of previous years.