Publications by authors named "M Rowan"
Background: Several organizations including the Environmental Protection Agency, World Health Organization and American Academy of Pediatrics recommend that hospital sound levels not exceed 45 decibels. Yet, several studies across multiple age groups have observed higher than recommended levels in the intensive care setting. Elevated sound levels in hospitals have been associated with disturbances in sleep, patient discomfort, delayed recovery, and delirium.
View Article and Find Full Text PDFSignificant technical challenges exist when measuring synaptic connections between neurons in living brain tissue. The patch clamping technique, when used to probe for synaptic connections, is manually laborious and time-consuming. To improve its efficiency, we pursued another approach: instead of retracting all patch clamping electrodes after each recording attempt, we cleaned just one of them and reused it to obtain another recording while maintaining the others.
View Article and Find Full Text PDFArticle Synopsis
- Alzheimer's disease is marked by cognitive decline due to the buildup of amyloid-β and tau proteins, which affect synaptic function and correlate with cognitive status.
- The study investigates the effects of synaptotoxic tau and amyloid-β on long-term depression in the hippocampus using animal models and various sources of these proteins.
- Results demonstrated that tau and amyloid-β from different origins similarly enhance long-term synaptic weakening, suggesting they both contribute to cognitive dysfunction in Alzheimer's disease.
Article Synopsis
- The study aimed to investigate the prevalence of squeezable food pouches among infants and young children, and their potential effects on energy intake and body mass index (BMI).
- Researchers surveyed 933 children in New Zealand, and found that while pouch usage decreased as children grew older, the effect on their energy intake varied by age.
- Notably, preschool children who frequently used pouches consumed less energy compared to non-users, while no significant differences in BMI were observed related to pouch use, suggesting concerns about pouches may be overstated.
Preventative treatment for Alzheimer's Disease (AD) is dire, yet mechanisms underlying early regional vulnerability remain unknown. In AD, one of the earliest pathophysiological correlates to cognitive decline is hyperexcitability, which is observed first in the entorhinal cortex. Why hyperexcitability preferentially emerges in specific regions in AD is unclear.
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