Polyphenols in Human Nutrition: European Regulations and Potential Classification as a Novel Food or Food Additive.

Polyphenols are widely present in botanicals and are partially responsible for the health benefits associated with plant-based diets. Due to their nutritional and health-promoting properties, polyphenols are increasingly being proposed as innovative food ingredients, whether for technological applications or for inclusion in food supplements and other food products to enhance health. However, the regulatory considerations surrounding the use of polyphenols in human nutrition are critical.

Lotus resistance against Ralstonia is enhanced by Mesorhizobium and does not impair mutualism.

Legumes establish nitrogen-fixing symbioses with rhizobia. On the contrary, they can be attacked concomitantly by pathogens, raising the question of potential trade-offs between mutualism and immunity. In order to study such trade-offs, we used a tripartite system involving the model legume Lotus japonicus, its rhizobial symbiont Mesorhizobium loti and the soilborne pathogen Ralstonia solanacearum.

Harnessing uncertainty: A deep mechanistic approach for cautious diagnostic and forecast of Bovine Respiratory Disease.

Bovine Respiratory Disease (BRD) is a prevalent infectious disease of respiratory tract in cattle, presenting challenges in accurate diagnosis and forecasting due to the complex interactions of multiple risk factors. Common methods, including mathematical epidemiological models and data-driven approaches such as machine learning models, face limitations such as difficult parameter estimation or the need for data across all potential outcomes, which is challenging given the scarcity and noise in observing BRD processes. In response to these challenges, we introduce a novel approach known as the Bayesian Deep Mechanistic method.

Toxicological evaluation of -derived molecule (PD-00105): genotoxicity studies and 90-day oral toxicity study in rats.

PD-00105 corresponds to a compound initially identified in the fruit of Miq., obtained by chemical synthesis and proposed to be use in dietary supplements for its potential neuroprotective properties. The aim of this study was to perform a toxicological evaluation of PD-00105 in accordance with the testing strategy recommended by food regulatory authorities.