Publications by authors named "M Rothermundt"
Article Synopsis
- * Researchers discovered 287 genomic regions associated with schizophrenia, emphasizing genes specifically active in excitatory and inhibitory neurons, and identified 120 key genes potentially responsible for these associations.
- * The findings highlight important biological processes related to neuronal function, suggesting overlaps between common and rare genetic variants in both schizophrenia and neurodevelopmental disorders, ultimately aiding future research on these conditions.
Article Synopsis
- Antidepressant treatment for major depressive disorder typically has low success rates, with over 50% of patients not responding well, leading to a trial-and-error approach to finding effective medication.
- A comprehensive study analyzed 258 serum markers in 332 patients to identify potential biomarkers for treatment response, revealing specific proteins linked to how well individuals respond to different antidepressants.
- Although some commonly cited markers were not confirmed, the study suggests that an individual's immune-endocrine profile could guide more personalized treatment strategies in the future.
Article Synopsis
- * Researchers analyzed serum from 65 MDD patients and found significant differences in proteins related to immune response and apolipoproteins across different staging models for TRD.
- * The findings suggest that certain proteins could help identify high-risk patients, but the subtle molecular changes need careful interpretation before clinical application.
Background: Schizophrenia can be conceptualized as a form of dysconnectivity between brain regions.To investigate the neurobiological foundation of dysconnectivity, one approach is to analyze white matter structures, such as the pathology of fiber tracks. S100B is considered a marker protein for glial cells, in particular oligodendrocytes and astroglia, that passes the blood brain barrier and is detectable in peripheral blood.
View Article and Find Full Text PDF