Publications by authors named "M Rossmeisl"
Postnatal surge of adipose-secreted leptin is a robust predictor of fat mass trajectory in mice.
Am J Physiol Endocrinol Metab
December 2024
Article Synopsis
- The study investigates how a temporary increase in leptin levels after birth, known as leptin surge, may influence future obesity risk in mice, particularly those genetically prone or resistant to obesity.
- The research specifically examines the sources of leptin during this surge and how factors like sex and genetics affect its role in weight gain when placed on different diets.
- Findings reveal that leptin levels at 2 weeks old can predict adult body weight and fat levels, highlighting the importance of early leptin exposure in determining obesity outcomes later in life.
Tissue-specific sex-dependent difference in the metabolism of fatty acid esters of hydroxy fatty acids.
Biochim Biophys Acta Mol Cell Biol Lipids
December 2024
Fatty acid esters of hydroxy fatty acids (FAHFAs) are endogenous bioactive lipids known for their anti-inflammatory and anti-diabetic properties. Despite their therapeutic potential, little is known about the sex-specific variations in FAHFA metabolism. This study investigated the role of sex and Androgen Dependent TFPI Regulating Protein (ADTRP), a FAHFA hydrolase.
View Article and Find Full Text PDFMetabolic dysfunction-associated steatotic liver disease (MASLD) occurs in subjects with obesity and metabolic syndrome. MASLD may progress from simple steatosis (i.e.
View Article and Find Full Text PDFAutophagy is an evolutionarily conserved process that plays a pivotal role in the maintenance of cellular homeostasis and its impairment has been implicated in the pathogenesis of various metabolic diseases including obesity, type 2 diabetes (T2D), and metabolic dysfunction-associated steatotic liver disease (MASLD). This review synthesizes the current evidence from human studies on autophagy alterations under these metabolic conditions. In obesity, most data point to autophagy upregulation during the initiation phase of autophagosome formation, potentially in response to proinflammatory conditions in the adipose tissue.
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