Publications by authors named "M Rosati"
Background: Vaginal delivery in twins is feasible but challenging. Successful vaginal delivery of a non-vertex second twin depends on knowledge of specific obstetrical maneuvers. Skill acquisition at the patient's bedside is difficult, making simulation training an integral part of obstetrics and gynecology residency programs.
View Article and Find Full Text PDFSelf-Assembly and Biological Properties of Highly Fluorinated Oligonucleotide Amphiphiles.
Angew Chem Int Ed Engl
December 2024
Article Synopsis
- Nucleic acids can effectively silence disease-related genes and have advantages over small molecule drugs, such as high specificity and the ability to target hard-to-reach molecules.
- However, their instability in biological settings and quick clearance from the body pose challenges, leading to the need for nanocarriers.
- Spherical nucleic acids (SNA) made from highly fluorinated DNA amphiphiles offer improved stability in biological media and promise better delivery of nucleic acid therapies for gene silencing.
Digital vs formal teaching of vaginal breech delivery: Which is the residents' choice?
Eur J Obstet Gynecol Reprod Biol
December 2024
Article Synopsis
- The study focuses on improving residents' training in managing breech deliveries, a critical skill in obstetrics, especially as vaginal deliveries of breech cases decline in favor of cesarean sections.
- A randomized controlled trial was conducted where obstetrics residents were divided into two groups: one received a formal lecture while the other used digital materials for home learning, with both groups evaluated through a simulation test.
- Results showed no significant differences in performance based on the type of learning, although the digital group scored slightly higher in some questionnaire aspects, indicating that both learning methods are effective in training for vaginal breech deliveries.
Persistent sciatic artery (PSA) is a rare vascular anomaly classified into five types according to the Pillet and Gauffre classification system. Although PSA may be detected as an incidental finding, symptomatic cases account for approximately 80% of all cases and have variable clinical presentations. Due to the frequent ischemic and aneurysmal complications, PSAs can lead to limb-threatening conditions requiring prompt identification and adequate treatment management.
View Article and Find Full Text PDFArticle Synopsis
- F nuclei are useful for monitoring protein interactions in NMR spectroscopy.
- While methods exist to add fluorine to proteins, techniques for mammalian cells are lacking.
- This study introduces an affordable method to create fluorotryptophan for use in proteins, specifically in carbonic anhydrase 2 and superoxide dismutase, using HEK cell expression.