Publications by authors named "M Rosario Rodicio"
Article Synopsis
- The subspecies serovar 4,12:i:- is a newly recognized variant of Typhimurium, which has become a global health concern in recent decades, with distinct clones identified across different regions, including Southern Europe and the U.S.
- This study specifically examined multidrug-resistant isolates from Spanish hospitals, highlighting that resistance genes are primarily located on unique IncR plasmids, which also contain virulence genes and show significant genetic diversity.
- The findings indicate that resistance in the Southern European clone evolves through both the diversification of existing plasmids and the acquisition of new ones, while specific genetic deletions contribute to its monophasic characteristics.
A dataset comprising metagenomes of outpatients (n = 28) with acute leukemia (AL) and healthy controls (n = 14) was analysed to investigate the associations between gut microbiota composition and metabolic activity and AL. According to the results obtained, no significant differences in the microbial diversity between AL outpatients and healthy controls were found. However, significant differences in the abundance of specific microbial clades of healthy controls and AL outpatients were found.
View Article and Find Full Text PDFBloodstream infections (BSI) caused by carbapenem-resistant are associated with high morbidity and mortality, and the therapy options available for their treatment are frequently scarce. The aim of this study was to analyze risk factors for 30-day mortality in patients with BSI caused by OXA-48-producing . The clinical and treatment features of the patients, who attended a single hospital over a five-year period, were retrospectively reviewed.
View Article and Find Full Text PDFUsefulness of inclusion of ertapenem and temocillin screening breakpoints in the EUCAST rapid antimicrobial susceptibility testing (RAST) for rapid detection of OXA-48-producing Klebsiella pneumoniae directly from positive blood cultures.
J Antimicrob Chemother
February 2024
Objectives: The aims of this study were: (i) to assess the ability of the meropenem screening breakpoint as part of the screening rapid antimicrobial susceptibility testing (sRAST) of EUCAST for the detection of OXA-48 carbapenemase-producing Klebsiella pneumoniae directly from positive blood cultures (BCs); and (ii) to evaluate the inclusion of ertapenem and temocillin discs into the sRAST to enhance the detection of OXA-48-producing isolates.
Methods: BC bottles were spiked with a total of 117 K. pneumoniae isolates, including 77 previously characterized OXA-48 producers and 40 non-OXA-48 producers.