Publications by authors named "M Rosales"
BMT CTN 1506 ("MORPHO"; NCT02997202) was a randomized phase 3 study of gilteritinib compared to placebo as maintenance therapy after hematopoietic stem cell transplantation (HCT) for patients with FLT3-ITD-mutated acute myeloid leukemia (AML). A key secondary endpoint was to determine the impact on survival of pre- and/or post-HCT measurable residual disease (MRD), as determined using a highly sensitive assay for FLT3-ITD mutations. Generally, gilteritinib maintenance therapy was associated with improved relapse-free survival (RFS) for participants with detectable peri-HCT MRD, whereas no benefit was evident for those lacking detectable MRD.
View Article and Find Full Text PDFBackground: Pose estimation (PE) has the promise to measure pediatric movement from a video recording. The purpose of this study was to quantify the accuracy of a PE model to detect arm and leg movements in 3-month-old infants with and without (TD, for typical development) complex congenital heart disease (CCHD).
Methods: Data from 12 3-month-old infants (N = 6 TD and N = 6 CCHD) were used to assess MediaPipe's full-body model.
Article Synopsis
- Infant vaccination rates in Peru have dropped recently, worsened by the COVID-19 pandemic, leading to a proposal to switch to a new hexavalent vaccine in the national immunization program to improve coverage.
- A cost-effectiveness analysis examined different vaccination scenarios over a 5-year period for nearly half a million children born in 2020, assessing various outcomes including coverage rates and healthcare costs.
- The analysis found that moving to the hexavalent vaccine could increase coverage significantly, with costs rising based on different delivery scenarios, highlighting the importance of effective vaccination strategies for public health.
Article Synopsis
- Engineering tissue implants using human induced pluripotent stem cells (hiPSCs) shows potential for repairing large tissue losses but faces challenges in survival and integration.* -
- The study introduces scalable vessel-integrated muscle-like lattices (VMLs) that feature dense hiPSC-derived myofibers and vessel-like microchannels, enhancing myofiber maturation and host integration.* -
- This advanced bioprinting technology allows for the creation of larger, prevascularized muscle tissues, which successfully restore muscle function and promote healing in volumetric muscle loss injury models.*
The development of new building elements, such as concrete and mortar with sustainable materials, which produce a lower carbon footprint, is an achievable milestone in the short term. The need to reduce the environmental impact of the production of cement-based materials is of vital importance. This work focuses on the evaluation of the life-cycle assessment, production costs, mechanical performance, and durability of three mortars and three concrete mixtures in which mixed recycled aggregates (MRAs) and biomass bottom ash from olive waste (oBBA) were included to replace cement and aggregates.
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