Publications by authors named "M Rorth"
Article Synopsis
- A nationwide study in Denmark found that influenza vaccination coverage among cancer patients is low, with just 14% for patients under 65 and 51% for those 65 and older.
- The strongest predictor of not getting vaccinated was having not received the vaccine in the previous season, with significantly higher risks for both age groups.
- Patients with haematological cancers who were undergoing chemotherapy were less likely to be vaccinated compared to those not receiving chemotherapy.
Objective: To evaluate whether optimized and standardized diagnostic procedures would improve detection of germ cell neoplasia in situ (GCNIS) in the contralateral testis of patients with testicular germ cell tumour (TGCT) and decrease the rate of metachronous tumours, which in a nationwide Danish study was estimated to be 1.9%.
Patients And Methods: This was a retrospective analysis of outcomes in 655 patients with TGCT who underwent contralateral biopsies (1996-2007) compared with those in 459 non-biopsied TGCT controls (1984-1988).
Article Synopsis
- Taxane-based chemotherapy is the primary treatment for premenopausal breast cancer, but genetic variants (SNPs) may impact drug effectiveness and patient outcomes.
- A study analyzing 2,262 premenopausal women found that certain SNPs affected breast cancer recurrence and mortality rates, with specific variants associated with increased mortality and decreased recurrence.
- The findings suggest that pharmacogenetic factors, particularly in genes like GSTP1, CYP3A, and SLCO1B1, may influence the effectiveness of chemotherapy drugs such as docetaxel.
Identifying Valid Algorithms for Number of Lines of Anti-Neoplastic Therapy in the Danish National Patient Registry Among Patients with Advanced Ovarian, Gastric, Renal Cell, Urothelial, and Non-Small Cell Lung Cancer Attending a Danish University Hospital.
Clin Epidemiol
February 2022
Purpose: To develop algorithms to identify number of lines of anti-neoplastic therapy per patient based on the Danish National Patient Registry (DNPR) and identify which algorithm has the highest percentage agreement with a reference standard of documentation in medical records.
Patients And Methods: We included 179 patients diagnosed between January 1, 2012, and December 31, 2016, with stage II, III, or IV urothelial cell carcinoma or stage III or IV epithelial ovarian cancer, gastric adenocarcinoma, renal cell carcinoma, or non-small cell lung cancer (NSCLC). We developed two algorithms for number of lines of anti-neoplastic therapy based on dates and treatment codes (eg, "treatment with cisplatin" or "cytostatic treatment") in the DNPR.
Aging of the population is a pressing challenge for healthcare systems and knowledge of a patient's prognosis is a key to shaping effective interventions. As the prevalence of multimorbidity strongly increases with age, the prognostic value of multiple disease diagnoses for survival among older people may diminish, whereas other measures of health, such as functional status (defined as a measure of an individual's ability to perform activities of daily living), may become more important. In this commentary, the impact of age on the prognostic value of multimorbidity is discussed, with the aim of identifying relevant alternative risk indicators for different age groups.
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