The possible role of the PK1 and its receptor in the etiology of the preeclampsia.

Objective: Preeclampsia (PE) is a hypertensive complication of the pregnancy. In our study we investigated the expression, localization, and signaling pathways of PK1 and PKR1 in third-trimester human placenta and myometrium and assessed the correlation between the PK1 and PKR1 expression and signaling and the incidence of the PE.

Materials & Methods: We designed two study groups: pregnant PE patients and healthy, pregnant women.