A collaborative network analysis for the interpretation of transcriptomics data in Huntington's disease.

Rare diseases may affect the quality of life of patients and be life-threatening. Therapeutic opportunities are often limited, in part because of the lack of understanding of the molecular mechanisms underlying these diseases. This can be ascribed to the low prevalence of rare diseases and therefore the lower sample sizes available for research.

Fracture load of feldspar ceramic crowns: effects of surface treatments and aging.

Objectives: To compare the impact of intaglio surface treatments - airborne particle abrasion and hydrofluoric acid (HF) etching - of feldspar ceramic (FEL) crowns on the fracture load (FL) and to investigate the effects of abutment materials and artificial aging. The aim was to assess whether etching could be replaced by an alternative surface roughening method.

Materials And Methods: FEL crowns had their intaglio surfaces either abraded (25 µm AlO, 0.

Starting postgraduate medical training in general practice with a rotation in general practice - a qualitative study on experiences and effects.

Objective: In Germany, the rotation into the general practitioner's practice (GPP) as part of postgraduate medical training in general practice traditionally takes place at the end of the training period. The aim of this study was to explore possible subsequent effects of beginning training in the GPP from the perspective of general practitioners (GPs) and GP trainees.

Methods: Nationwide, GPs and GP trainees were recruited who started specialization in GP in the GPP.

Organoid intelligence for developmental neurotoxicity testing.

The increasing prevalence of neurodevelopmental disorders has highlighted the need for improved testing methods to determine developmental neurotoxicity (DNT) hazard for thousands of chemicals. This paper proposes the integration of organoid intelligence (OI); leveraging brain organoids to study neuroplasticity into the DNT testing paradigm. OI brings a new approach to measure the impacts of xenobiotics on plasticity mechanisms - a critical biological process that is not adequately covered in current DNT assays.

Workplace Injury Prevention and Wellness Program for Orchestra Musicians: A Randomized Controlled Trial.

To evaluate the effect of a workplace injury prevention and wellness program compared to no intervention (control) on musicians' playing-related musculoskeletal pain intensity. The hypothesis was that musicians who completed the program would have a greater reduction in pain intensity than the control group. Pragmatic parallel randomized controlled trial.