Publications by authors named "M Ronci"
N-myc downstream-regulated gene 1 (NDRG1) is a member of the NDRG family of intracellular proteins and plays a central role in a wide range of biological processes including stress response, differentiation, and metabolism. The overexpression of NDRG1 is an indicator of poor prognosis in various types of cancer. Here, we found that NDRG1 is an independent prognostic marker of poor outcome in breast cancer (BC).
View Article and Find Full Text PDFNeuroinflammation is a critical aspect of various neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases. This study investigates the anti-neuroinflammatory properties of oleocanthal and its oxidation product, oleocanthalic acid, using the BV-2 cell line activated with lipopolysaccharide. Our findings revealed that oleocanthal significantly inhibited the production of pro-inflammatory cytokines and reduced the expression of inflammatory genes, counteracted oxidative stress induced by lipopolysaccharide, and increased cell phagocytic activity.
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- The SNP rs4644 is a genetic change that affects a protein called galectin-3 (gal-3) and is linked to the risk of some cancers, including thyroid cancer.
- Researchers studied two types of cells with different versions of this SNP to understand how it changes the proteins made by those cells.
- They found that the SNP influences how gal-3 is formed and how it works, which might explain why some people are more likely to get certain diseases.
Dietary fiber has been shown to have multiple health benefits, including a positive effect on longevity and the gut microbiota. In the present study, has been chosen as an model organism to study the health effects of dietary fiber supplementation (DFS). DFS extended the mean half-life of male and female flies, but the absolute lifespan only increased in females.
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- The Mediterranean diet may have protective effects on the brain through its influence on gut microbiota via the gut-brain axis.
- A study using a rodent model found that a blend resembling the Mediterranean diet (Neurosyn240) improved cognitive function after inflammation, as evidenced by behavioral tests.
- Changes in gut microbiota and brain proteomics were linked to improved memory and cognitive performance, indicating potential pathways for neuroprotection through diet.