[The application of pudendal nerve blockade in the treatment of pudendal neuralgia related chronic pelvic pain].

Pudendal neuralgia is a rare and — in the absence of somatic, radiological and laboratory abnormalities — often unrec-ognizable problem, posing a serious challenge to therapeutic management. Our case study presents the complete diagnostic and therapeutic algorithm of a female patient with chronic pudendal pain. In addition, our paper draws attention to the role of pelvic pain workgroups — such as the Pelvic Pain Task Force of the Semmelweis University — where cases of chronic pelvic pain with no clear medical reason can be assessed and treated with higher efficiency.

Signaling Pathways Mediating Bradykinin-Induced Contraction in Murine and Human Detrusor Muscle.

Bradykinin (BK) has been proposed to modulate urinary bladder functions and implicated in the pathophysiology of detrusor overactivity. The present study aims to elucidate the signaling pathways of BK-induced detrusor muscle contraction, with the goal of better understanding the molecular regulation of micturition and identifying potential novel therapeutic targets of its disorders. Experiments have been carried out on bladders isolated from wild-type or genetically modified [smooth muscle-specific knockout (KO): Gα-KO, Gα-KO and constitutive KO: thromboxane prostanoid (TP) receptor-KO, cyclooxygenase-1 (COX-1)-KO] mice and on human bladder samples.

[The treatment of overactive bladder syndrome with onabotulinumtoxinA therapy].

Introduction: Overactive bladder syndrome is an endemic phenomenon, which has a significant impact on the quality of life. In cases where conservative treatment fails, intradetrusor onabotulinumtoxinA injection can be used as second-line therapy. Objective: To assess the safety and efficacy of onabotulinumtoxinA treatment in the management of non-neurogenic detrusor overactivity among our patients.

Narrow Vagina as a Predictor of Obstructive Voiding Dysfunction after Transobturator Sling Surgery.

Background: Voiding dysfunction (VD) is a potential complication after female midurethral sling operations.

Objectives: Our goal was to assess the rate of obstructive VD after -transobturator tension-free tape (TOT) procedures and to find perioperative risk factors (RFs) predicting postoperative voiding problems.

Methods: We have retrospectively evaluated the perioperative data of 397 women who underwent TOT operations.