Publications by authors named "M Roll"
Heschl's gyrus and the temporal pole: The cortical lateralization of language.
Neuroimage
December 2024
The left lateralization of language has been attributed to hemispheric specialization for processing rapidly changing information. While interhemispheric differences in auditory cortex organization support this view, the macrostructure of the entire cerebral cortex has not been thoroughly examined from this perspective. This study investigated hemispheric asymmetries in cortical surface area and thickness and their relationship to pronunciation scores from oral reading using the Human Connectome Project Young Adult dataset (N=1113).
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- Age-related macular degeneration (AMD) and related macular dystrophies (MDs) primarily impact the retinal pigment epithelium (RPE) with drusen deposits being a key feature in the progression of these diseases.
- The research indicates that reduced activity of matrix metalloproteinase 2 (MMP2) in RPE contributes to drusen formation by causing sterile inflammation and disrupting lipid balance, interacting with specific receptors and molecules.
- Therapeutic approaches including MMP2 supplementation and inhibiting RAGE and sPLA2-IIA have shown promise in reducing drusen accumulation in patient-derived RPE cells, highlighting a potential treatment pathway for AMD/MDs.
The temporal dynamics of the perception of within-word coarticulatory cues remain a subject of ongoing debate in speech perception research. This behavioral gating study sheds light on the unfolding predictive use of anticipatory coarticulation in onset fricatives. Word onset fricatives (/f/ and /s/) were split into four gates (15, 35, 75 and 135 milliseconds).
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- Research is focused on finding new biologically active compounds, specifically Azothioformamides (ATFs), which can form stable coordination complexes with metals like copper for potential anticancer and antimicrobial therapies.
- In this study, different ATF ligands with varying heterocyclic groups were synthesized and complexed with Cu(I) salts, which were chosen for their potential lower toxicity and effective binding properties.
- The results indicated that smaller pyrrolidine-substituted ATFs showed stronger binding to Cu(I) salts and had varying levels of antimicrobial activity, particularly against some cancer cell lines, while the ATF ligands alone showed limited effectiveness.
This study investigated whether the brain utilizes morphologically induced tones for semantic processing during online speech perception. An auditory comprehension task was conducted while measuring event-related potentials (ERPs). The study tested whether a discrepancy between contextual expectations and the tonal realizations of the target word would yield an N400 effect, indicative of semantic processing difficulty.
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