Publications by authors named "M Rojiani"
Lung cancer is one of the leading causes of cancer-related mortality worldwide among men and women [...
View Article and Find Full Text PDFThe development of chemoresistance remains a significant barrier to treating NSCLC. Alteration of cancer cell metabolism is an important mechanism for chemoresistance. This study explored the role of aberrant metabolism in TIMP-1-mediated chemoresistance.
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- Renal cancer is a serious urogenital disease, but immunotherapy has improved patient management significantly in recent years.
- Despite its benefits, challenges like high treatment costs, lack of predictive biomarkers, and toxic side effects hinder broader use.
- Recent advancements in single-cell sequencing and transcriptomics have helped identify new gene signatures that could lead to personalized treatment strategies and better predictions for renal cancer patients.*
Non-small cell lung cancer (NSCLC) is a major subtype of lung cancer that accounts for almost 85% of lung cancer cases worldwide. Although recent advances in chemotherapy, radiotherapy, and immunotherapy have helped in the clinical management of these patients, the survival rate in advanced stages remains dismal. Furthermore, there is a critical lack of accurate prognostic and stratification markers for emerging immunotherapies.
View Article and Find Full Text PDFComplex interactions in tumor microenvironment between ECM (extra-cellular matrix) and cancer cell plays a central role in the generation of tumor supportive microenvironment. In this study, the expression of ECM-related genes was explored for prognostic and immunological implication in clear cell renal clear cell carcinoma (ccRCC). Out of 964 ECM genes, higher expression (z-score > 2) of 35 genes showed significant association with overall survival (OS), progression-free survival (PFS) and disease-specific survival (DSS).
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