Publications by authors named "M Rojas-Lemus"
Malaria represents the greatest global health burden among all parasitic diseases, with drug resistance representing the primary obstacle to control efforts. Sodium metavanadate (NaVO) exhibits antimalarial activity against the Plasmodium yoelii yoelii (Pyy), yet its precise antimalarial mechanism remains elusive. This study aimed to assess the antimalarial potential of NaVO, evaluate its genotoxicity, and determine the production of reactive oxygen and nitrogen species (ROS/RNS) in Pyy.
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- The non-ciliated bronchiolar cell, known as the "club cell," plays a crucial role in the airway epithelium, primarily located in the bronchioles of humans and found prominently in rodents.
- Club cells serve multiple functions, acting as regulatory cells in lung inflammation and as stem cells for lung epithelial regeneration.
- This review aims to explore club cell structure and function under normal and disease conditions to enhance the understanding of their significance in the respiratory system.
(Pc) is a fern that, according to ethnobotanical records, is used in Mexican traditional medicine to treat gastrointestinal ailments. Recent reports indicate that the hexane fraction (Hf) obtained from Pc methanolic frond extract affects tachyzoite viability in vitro; therefore, in the present study, the activity of different Pc hexane subfractions (Hsf) obtained by chromatographic methods was evaluated in the same biological model. Gas chromatography/mass spectrometry (GC/MS) analysis was carried out for hexane subfraction number one (Hsf1), as it showed the highest anti- activity with a half-maximal inhibitory concentration (IC) of 23.
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- The non-ciliated bronchiolar cell (NCBC) in the lungs defends against harmful substances and increases mucin and CC16 protein production in response to exposure to toxins.
- A study explored how male and female CD-1 mice reacted differently to inhaling vanadium (V) over four weeks, finding that both sexes experienced hyperplasia and NCBC sloughing but had varying levels of mucosecretory metaplasia.
- Results showed increased expression of CC16 in both genders, but male mice exhibited more severe changes, indicating significant differences in susceptibility to toxic inhalants based on sex.
Apicomplexan parasites are the causal agents of different medically important diseases, such as toxoplasmosis, cryptosporidiosis, and malaria. Toxoplasmosis is considered a neglected parasitosis, even though it can cause severe cerebral complications and death in immunocompromised patients, including children and pregnant women. Drugs against , the etiological agent of toxoplasmosis, are highly toxic and lack efficacy in eradicating tissue cysts, promoting the establishment of latent infection and acute relapsing disease.
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