Publications by authors named "M Rogalska"
Article Synopsis
- Aurora-A kinase is a potential target for cancer therapies, but its inhibition can also cause toxic side effects.
- Recent research used shotgun proteomics to identify 407 protein partners of Aurora-A, showing it plays a significant role in alternative splicing by interacting with and phosphorylating splicing factors.
- The study found that inhibiting Aurora-A affects the splicing of 505 genes and revealed a positive correlation between splicing events regulated by Aurora-A and its interacting splicing factors, highlighting its important role in alternative splicing regulation.
The spliceosome is the complex molecular machinery that sequentially assembles on eukaryotic messenger RNA precursors to remove introns (pre-mRNA splicing), a physiologically regulated process altered in numerous pathologies. We report transcriptome-wide analyses upon systematic knock down of 305 spliceosome components and regulators in human cancer cells and the reconstruction of functional splicing factor networks that govern different classes of alternative splicing decisions. The results disentangle intricate circuits of splicing factor cross-regulation, reveal that the precise architecture of late-assembling U4/U6.
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- - Background information indicates that liver damage is a key factor in acute COVID-19 cases, and existing liver conditions worsen patient outcomes.
- - A study analyzed data from 7,444 patients to assess liver damage markers and their links to mortality and the need for mechanical ventilation (MV).
- - Results showed that higher levels of specific liver enzymes and scores (like ALT, AST, and FIB-4) correlate with greater mortality risk, while LDH was especially predictive for needing MV, highlighting the importance of monitoring liver function in COVID-19 patients.
Iron plays a crucial role in various metabolic processes. However, the impact of 5-aminolevulinic acid (ALA) in combination with iron chelators on iron metabolism and the efficacy of ALA-photodynamic therapy (PDT) remain inadequately understood. This study aimed to examine the effect of thiosemicarbazone derivatives during ALA treatment on specific genes related to iron metabolism, with a particular emphasis on mitochondrial iron metabolism genes.
View Article and Find Full Text PDFThe aim of this study was to obtain drinking yogurts enriched with ACTICOA cocoa powder (ACTICOA), its extract (EACTICOA) and pure phenolics, as well as their inclusion complexes with cyclodextrins and alginate-chitosan (A-Ch) capsules, and to evaluate the effects of these additives on the viability of lactic acid bacteria (LAB) and antioxidant properties of fresh yogurts and yogurts stored for 14 days at 4 °C. The application of cocoa phenolic compounds in free form and in the form of EACTICOA to yogurts resulted in the greatest increase in the concentration of phenolic compounds and a significant improvement in the antioxidant properties of the fortified products. The highest TPC was found in yogurts enriched with free quercetin (107.
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