Publications by authors named "M Rodriguez-Pena"

Article Synopsis
  • Dimorphism is a phenomenon where certain fungi can switch between yeast and filamentous forms depending on temperature, which is explored in the study of a new mucoralean fungus isolated from a patient with Burkitt lymphoma.
  • The fungus shows significant changes in shape and structure at body temperature, resembling traditional yeast forms but still having unique features that can help differentiate it from other similar fungi in clinical settings.
  • Accurate and timely diagnosis is crucial for managing mucormycosis, as different fungal species have varied responses to antifungal treatments, highlighting the need to recognize these dimorphic transitions to improve patient outcomes.
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Pancreatic β-cell dysfunction is a key feature of type 2 diabetes, and novel regulators of insulin secretion are desirable. Here we report that the succinate receptor (SUCNR1) is expressed in β-cells and is up-regulated in hyperglycemic states in mice and humans. We found that succinate acts as a hormone-like metabolite and stimulates insulin secretion via a SUCNR1-Gq-PKC-dependent mechanism in human β-cells.

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Experimental autoimmune orchitis (EAO) is a well-established rodent model of organ-specific autoimmunity associated with infertility in which the testis immunohistopathology has been extensively studied. In contrast, analysis of testis biopsies from infertile patients associated with inflammation has been more limited. In this work, testicular biopsies from patients with idiopathic non-obstructive azoospermia diagnosed with hypospermatogenesis (HypoSp) [mild: = 9, and severe: = 11], with obstructive azoospermia and complete Sp (spermatogenesis) (control group, C, = 9), and from Sertoli cell-only syndrome (SCOS, = 9) were analyzed for the presence of immune cells, spermatogonia and Sertoli cell (SCs) alterations, and reproductive hormones levels.

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Objective: To determine changes in incretins, systemic inflammation, intestinal permeability and microbiome modifications 12 months after metabolic RYGB (mRYGB) in patients with type 2 diabetes (T2D) and their relationship with metabolic improvement.

Materials And Methods: Prospective single-center non-randomized controlled study, including patients with class II-III obesity and T2D undergoing mRYGB. At baseline and one year after surgery we performed body composition measurements, biochemical analysis, a meal tolerance test (MTT) and lipid test (LT) with determination of the area under the curve (AUC) for insulin, C-peptide, GLP-1, GLP-2, and fasting determinations of succinate, zonulin, IL-6 and study of gut microbiota.

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Periodontitis is one of the most prevalent human inflammatory diseases. It is characterized by periodontal tissue destruction, progressively driven by the host response. In this regard, cytokines associated with tissue destruction, such as interleukin (IL)-6 and IL-23, use a common signaling pathway mediated by STAT3.

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