Publications by authors named "M Rochat"
Article Synopsis
- The study investigates how sulcal morphometry, which looks at the shape and structure of brain folds, can help predict whether patients with mild cognitive impairment (MCI) will progress to Alzheimer's disease (AD).
- Using MRI scans, researchers analyzed brain data from patients with AD, those with MCI, and healthy controls, particularly focusing on certain sulci (brain grooves).
- Results showed that changes in the width of specific sulci, especially in the temporo-occipital and frontal regions, were significant indicators for differentiating between patients who would convert to AD and those who would not, along with correlations to cognitive performance.
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with a strong genetic component in which rare variants contribute significantly to risk. We performed whole genome and/or exome sequencing (WGS and WES) and SNP-array analysis to identify both rare sequence and copy number variants (SNVs and CNVs) in 435 individuals from 116 ASD families. We identified 37 rare potentially damaging de novo SNVs (pdSNVs) in the cases (n = 144).
View Article and Find Full Text PDFAutism spectrum disorder (ASD) is a complex neurodevelopmental condition with a strong genetic component in which rare variants contribute significantly to risk. We have performed whole genome and/or exome sequencing (WGS and WES) and SNP-array analysis to identify both rare sequence and copy number variants (SNVs and CNVs) in 435 individuals from 116 ASD families. We identified 37 rare potentially damaging de novo SNVs (pdSNVs) in cases (n = 144).
View Article and Find Full Text PDFStudies showing that the management of dyslipidemia is suboptimal are hampered by their cross-sectional design or short follow-up. Using recent data from a population-based cohort with a 10-year follow-up, we assessed the use of statins, including their intensity. We used data from the CoLaus|PsyColaus study, involving 4,655 participants at baseline (2003 to 2006) and 3,587 at 10-year follow-up (2014 to 2017).
View Article and Find Full Text PDFAutism spectrum disorder (ASD) is a clinically heterogeneous class of neurodevelopmental conditions with a strong, albeit complex, genetic basis. The genetic architecture of ASD includes different genetic models, from monogenic transmission at one end, to polygenic risk given by thousands of common variants with small effects at the other end. The mitochondrial DNA (mtDNA) was also proposed as a genetic modifier for ASD, mostly focusing on maternal mtDNA, since the paternal mitogenome is not transmitted to offspring.
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