Publications by authors named "M Rocchetti"

Coronary artery calcium (CAC) score is a neglected biomarker that can be derived from non-cardiac chest computed tomography scan and represents a surrogate for atherosclerosis. We created a simulation model using different CAC score values in the MESA coronary artery risk score in a population derived from the Fourier Trial. CAC score could modulate the sample sizes of cardiovascular trials in primary and secondary prevention and offer new primary prevention treatments to high-risk subjects with reasonable numbers needed to treat comparable to secondary prevention trials.

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Article Synopsis
  • The study investigated Algerian dairy lactic acid bacteria strains VR81 and LVT1 from camel milk to discover their potential for producing a plant-based yogurt using quinoa as a base.
  • The selected strains showed promising probiotic properties, including resilience to harsh conditions and a strong ability to inhibit harmful bacteria, attributed to bioactive peptides.
  • The fermentation process using these strains effectively acidified quinoa, resulting in a high-quality fermented product enriched in beneficial metabolites like exopolysaccharides and riboflavin.
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Microglia are macrophage cells residing in the brain, where they exert a key role in neuronal protection. Through the gut-brain axis, metabolites produced by gut commensal microbes can influence brain functions, including microglial activity. The nuclear factor erythroid 2-related factor 2 (NRF2) is a key regulator of the oxidative stress response in microglia, controlling the expression of cytoprotective genes.

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Neurodegenerative disorders are the main cause of cognitive and physical disabilities, affect millions of people worldwide, and their incidence is on the rise. Emerging evidence pinpoints a disturbance of the communication of the gut-brain axis, and in particular to gut microbial dysbiosis, as one of the contributors to the pathogenesis of these diseases. In fact, dysbiosis has been associated with neuro-inflammatory processes, hyperactivation of the neuronal immune system, impaired cognitive functions, aging, depression, sleeping disorders, and anxiety.

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