Sex-Based Differences in Ruptured Abdominal Aortic Aneurysm Management and Outcomes: An Update.

Objectives: This study aimed to evaluate sex-based differences in outcomes following ruptured abdominal aortic aneurysm (AAA) repair, focusing on mortality, morbidity, and postoperative complications.

Design: Retrospective cohort study SETTING: Multi-institutional data from the Vascular Quality Initiative national database, covering a period from January 2003 to December 2022.

Participants: We included 7,548 patients undergoing open or endovascular repair for ruptured AAA: 5,829 men (77.

TMCO1 is upregulated in breast cancer and regulates the response to pro-apoptotic agents in breast cancer cells.

The release of Ca ions from endoplasmic reticulum calcium stores is a key event in a variety of cellular processes, including gene transcription, migration and proliferation. This release of Ca often occurs through inositol 1,4,5-triphosphate receptors and the activity of these channels and the levels of stored Ca in the endoplasmic reticulum are important regulators of cell death in cancer cells. A recently identified Ca channel of the endoplasmic reticulum is transmembrane and coiled-coil domains 1 (TMCO1).

Yb-based high dose rate intensity modulated brachytherapy for focal treatment of prostate cancer.

Purpose: This study compares conventional Ir-based high dose rate brachytherapy (HDR-BT) with Yb-based HDR intensity modulated brachytherapy (IMBT) for focal prostate cancer treatment. Additionally, the study explores the potential to generate less invasive treatment plans with IMBT by reducing the number of catheters needed to achieve acceptable outcomes.

Methods And Materials: A retrospective dosimetric study of ten prostate cancer patients initially treated with conventional Ir-based HDR-BT and 5-14 catheters was employed.

Cellular geometry and epithelial-mesenchymal plasticity intersect with PIEZO1 in breast cancer cells.

Differences in shape can be a distinguishing feature between different cell types, but the shape of a cell can also be dynamic. Changes in cell shape are critical when cancer cells escape from the primary tumor and undergo major morphological changes that allow them to squeeze between endothelial cells, enter the vasculature, and metastasize to other areas of the body. A shift from rounded to spindly cellular geometry is a consequence of epithelial-mesenchymal plasticity, which is also associated with changes in gene expression, increased invasiveness, and therapeutic resistance.

Topographical depth reveals contact guidance mechanism distinct from focal adhesion confinement.

Cellular response to the topography of their environment, known as contact guidance, is a crucial aspect to many biological processes yet remains poorly understood. A prevailing model to describe cellular contact guidance involves the lateral confinement of focal adhesions (FA) by topography as an underlying mechanism governing how cells can respond to topographical cues. However, it is not clear how this model is consistent with the well-documented depth-dependent contact guidance responses in the literature.