Macrophages and platelets in liver fibrosis and hepatocellular carcinoma.

During fibrosis, (myo)fibroblasts deposit large amounts of extracellular matrix proteins, thereby replacing healthy functional tissue. In liver fibrosis, this leads to the loss of hepatocyte function, portal hypertension, variceal bleeding, and increased susceptibility to infection. At an early stage, liver fibrosis is a dynamic and reversible process, however, from the cirrhotic stage, there is significant progression to hepatocellular carcinoma.

AirMLP: A Multilayer Perceptron Neural Network for Temporal Correction of PM2.5 Values in Turin.

In recent times, pollution has emerged as a significant global concern, with European regulations stipulating limits on PM 2.5 particle levels. Addressing this challenge necessitates innovative approaches.

Intravital Imaging of Thrombosis Models in Mice.

Intravital microscopy is a powerful tool to study thrombosis in real time. The kinetics of thrombus formation and progression is studied after inflicting damage to the endothelium through mechanical, chemical, or laser injury. Mouse models of atherosclerosis are also used to induce thrombus formation.

Relative Pain Reduction and Duration of Nerve Block Response Predict Outcomes in Headache Surgery: A Prospective Cohort Study.

Background: Experts agree that nerve block (NB) response is an important tool in headache surgery screening. However, the predictive value of NBs remains to be proven in a prospective fashion.

Methods: Pre-NB and post-NB visual analogue pain scores (0 to 10) and duration of NB response were recorded prospectively.

Evidence-Based Patient Selection in Headache Surgery: Impact of Preoperative Radiofrequency Ablation on Surgical Outcomes.

Background: Radiofrequency ablation (RFA) of the greater occipital nerve (GON) is a minimally invasive treatment option commonly used in patients with occipital neuralgia. Patients who undergo occipital surgery for headaches after failed RFA treatment present a unique opportunity to evaluate RFA-treated occipital nerves and determine the impact on headache surgery outcomes.

Methods: Of 115 patients who underwent headache surgery at the occipital site, 29 had a history of RFA treatment.