Publications by authors named "M Rijntjes"
Delayed therapy escape (DTE) is frequent after thalamic deep brain stimulation for essential tremor, leading to reduced quality of life, often with ataxic symptoms, and early recognition is challenging. Our goal was to examine whether a low-frequency rebound tremor of the left hand after switching off stimulation is useful as a diagnostic marker for DTE. In this cross-sectional study with additional retrospective analysis, we examined 31 patients with bilateral thalamic DBS ≥ 12 months for essential tremor, using quantitative assessments including video-based motion capture, Fahn-Tolosa-Marin Tremor Rating Scale (FTMTRS), and scale for the assessment and rating of ataxia (SARA).
View Article and Find Full Text PDFTime to bury the chisel: a continuous dorsal association tract system.
Brain Struct Funct
September 2024
The arcuate fasciculus may be subdivided into a tract directly connecting frontal and temporal lobes and a pair of indirect subtracts in which the fronto-temporal connection is mediated by connections to the inferior parietal lobe. This tripartition has been advanced as an improvement over the centuries-old consensus that the lateral dorsal association fibers form a continuous system with no discernible discrete parts. Moreover, it has been used as the anatomical basis for functional hypotheses regarding linguistic abilities.
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- Patients with Lewy body diseases, including Parkinson's disease and related dementias, have a higher risk of dementia, which significantly affects survival rates.
- A study analyzed cerebral glucose metabolism using PET scans and found that lower metabolism in specific brain regions predicted shorter survival, with significant differences in median survival based on the severity of metabolic decline.
- The findings suggest that PET scans could be a valuable tool for earlier predictions of survival in these patients, potentially aiding in treatment decisions, such as whether to consider deep brain stimulation.
Introduction: Silent pauses are regarded as integral components of the temporal organization of speech. However, it has also been hypothesized that they serve as markers for internal cognitive processes, including word access, monitoring, planning, and memory functions. Although existing evidence across various pathological populations underscores the importance of investigating silent pauses' characteristics, particularly in terms of frequency and duration, there is a scarcity of data within the domain of post-stroke aphasia.
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- The study investigates how the microstructural integrity of specific brain areas (substantia nigra, subthalamic nucleus, putamen) relates to the effectiveness of deep brain stimulation (DBS) in patients with Parkinson's disease.
- It involved 23 Parkinson's patients who underwent advanced MRI to assess brain microstructure before receiving STN-DBS and measured their motor improvements afterward.
- Results indicated a trend where poorer response to DBS correlated with increased free interstitial fluid in the substantia nigra and subthalamic nucleus, suggesting these areas may serve as biomarkers for predicting treatment outcomes, but further research is needed for definitive conclusions.