Pneumoperitoneum induced mesothelial cell changes in a laparoscopic mouse model.

Background: CO pneumoperitoneum (PP) during laparoscopic surgery, can cause hypoxia and desiccation in the peritoneal mesothelial cell, resulting in a time-dependent retraction and bulging of these cells, an acute inflammatory reaction and enhanced adhesion formation. Since hypoxia is prevented by adding 4% of oxygen (O) to the CO PP, the aim of this study was to evaluate the effect of adding 4% O to the CO PP on mesothelial cell morphology.

Methods: In a standardized laparoscopic mouse model (n=8 mice per group), a control group with a 30- or 60-min PP with humidified CO + 4% of O (groups I and II) was compared to a hypoxic group with 30- or 60-min humidified pure CO (groups III and IV) and a desiccation group with 60-min of dry CO PP (group V).

Intra- and interobserver variability in nodule size of rectosigmoid endometriosis measured by two- and three-dimensional transvaginal sonography.

Introduction: The aim of the study was to assess the intra- and interobserver variability of two- and three-dimensional rectosigmoid nodule size measurements by transvaginal sonography in patients with rectosigmoid endometriosis.

Material And Methods: Intra- and interobserver variability was assessed in 10 and 30 patients, respectively. Measurements in two dimensions were performed in real-time during the scan, and three-dimensional measurements of volume were done on a computer.

Risk of bowel obstruction during in vitro fertilization treatment of patients with deep infiltrating endometriosis.

Introduction: Women with endometriosis often experience pain and infertility. Medical treatment interferes with the possibility of attaining pregnancy. For infertile women with endometriosis, surgery is a possible treatment, but with advanced disease there is an increased risk of serious complications.

Bowel Endometriosis Syndrome: a new scoring system for pelvic organ dysfunction and quality of life.

Study Question: Is it possible to develop a validated score that can identify women with Bowel Endometriosis Syndrome (BENS) and be used to monitor the effect of medical and surgical treatment?

Summary Answer: The BENS score can be used to identify women with BENS and to monitor the effect of medical and surgical treatment of women suffering from bowel endometriosis.

What Is Known Already: Endometriosis is a heterogeneous disease with extensive variation in anatomical and clinical presentation, and symptoms do not always correspond to the disease burden. Current endometriosis scoring systems are mainly based on anatomical and surgical findings.