Publications by authors named "M Rieder"
A comprehensive update on the and idiosyncratic adverse drug reactions.
Expert Opin Drug Metab Toxicol
January 2025
Introduction: Idiosyncratic adverse drug reactions (IADRs) or drug hypersensitivity reactions (DHRs) represent a major health problem because they are unpredictable and can be severe with potential life-long or even lethal consequences. Their pathophysiology is not clear but thought to be immune mediated, supported by the significant statistical association of these reactions with specific alleles of the () gene.
Area Covered: This comprehensive update review summarizes the currently available evidence on the role of gene locus in IADRs and discusses the present understanding of the pathophysiology of IADRs.
This study evaluates the mechanical properties of materials used in the post-endodontic restoration of root-treated teeth and examines their performance under stress to provide insights for material selection in clinical applications. Particular attention is given to zirconium oxide, which demonstrates promising characteristics due to its esthetic color and favorable material properties, positioning it as a potential material for future use in post-endodontic treatments. Three materials-prefabricated quartz fiber-reinforced composite, milled zirconium oxide, and additively manufactured cobalt-chromium-were evaluated using compressive-deflection tests.
View Article and Find Full Text PDFPrecision medicine, which among other aspects includes an individual's genomic data in diagnosis and management, has become the standard-of-care for Mendelian cardiovascular disease (CVD). However, early identification and management of asymptomatic patients with potentially lethal and manageable Mendelian CVD through screening, which is the promise of precision health, remains an unsolved challenge. The reduced costs of genomic sequencing have enabled the creation of biobanks containing in-depth genetic and health information, which have facilitated the understanding of genetic variation, penetrance, and expressivity, moving us closer to the genotype-first screening of asymptomatic individuals for Mendelian CVD.
View Article and Find Full Text PDFUnlabelled: The study aimed to analyze the public interest in wisdom teeth-related search terms as well as regional and seasonal trends based on information from the Google search engine.
Methods: With the help of the online search query tool, Google Trends, the public interest in the primary search term "wisdom teeth" for the timeframe between January 1st, 2004 and September 31st, 2021 was analyzed. To do so, a country-specific search was conducted in English-speaking countries (the USA, the UK, Canada, and Australia) in the northern and southern hemispheres.
Article Synopsis
- Pathogenic/likely pathogenic (P/LP) desmin variants are linked to various cardiomyopathy and skeletal myopathy phenotypes, with a notable incidence of major adverse cardiac events (MACE) like cardiac conduction disease, arrhythmias, and heart failure.
- A systematic review of 71 studies involving 230 patients showed that over half of the patients were diagnosed with cardiomyopathy, primarily dilated cardiomyopathy, and many experienced significant cardiac events during their follow-ups.
- The research highlighted that familial penetrance of cardiac issues in relatives with P/LP variants was quite high at 63.6%, and male patients were more likely to develop severe outcomes linked to these variants.